alexa The Drug Target Enzyme Adenosine-5' -Phosphosulfate Reductases in the Sulfate Reductive Pathway from Various Living Organisms | OMICS International | Abstract
ISSN: 2168-9652

Biochemistry & Physiology: Open Access
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Review Article

The Drug Target Enzyme Adenosine-5' -Phosphosulfate Reductases in the Sulfate Reductive Pathway from Various Living Organisms

Megan E. Hermann, Myung K. Cho and Sung-Kun Kim*
Department of Chemistry and Biochemistry, Baylor University, Waco, TX, 76798-7348, USA
*Corresponding Author : Sung-Kun Kim
Department of Chemistry and Biochemistry
Baylor University, Waco
TX, 76798-7348, USA
Tel: 12547102581
Fax: +12547104272
E-mail: [email protected]
Received January 09, 2013; Accepted January 17, 2013; Published January 22, 2013
Citation: Hermann ME, Cho MK, Kim SK (2013) The Drug Target Enzyme Adenosine-5’-Phosphosulfate Reductases in the Sulfate Reductive Pathway from Various Living Organisms. Biochem Physiol 2:105. doi:10.4172/2168-9652.1000105
Copyright: © 2013 Hermann ME, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Organisms must metabolize sulfur to survive. The amino acids cysteine and methionine contain sulfur, and essential biomolecules such as thiamine, lipoic acid, and glutathiones also require this element. The most abundant form of sulfur in nature is sulfate. Organisms utilize the sulfate reduction pathway to reduce sulfate to sulfide, which changes the oxidation number from +6 to -2. In order to completely understand the sulfate reductive pathway, gaining knowledge of enzymes that are responsible for the metabolism of sulfur is of paramount importance. There are two branches in the pathway, which require two distinct enzymes: 3’-phosphoadenosine-5’-phosphosulfate (PAPS) reductase and adenosine-5’-phosphosulfate (APS) reductase. While PAPS reductases are found in microbes, APS reductases are found in a variety of organisms, ranging from bacteria to plants. This publication reviews APS reductases in the sulfate reductive pathway from various living organisms and the regulation and inhibition of sulfur metabolism. Since APS reductase is a fundamental enzyme in the element biosynthesis pathway, the enzyme offers an attractive venue for drug discovery.

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