alexa

GET THE APP

The Electromechanical Mechanism of ATP Synthesis in the Presence of In Vivo Concentrations of Oxygen | OMICS International | Abstract
ISSN: 2168-9652

Biochemistry & Physiology: Open Access
Open Access

Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

The Electromechanical Mechanism of ATP Synthesis in the Presence of In Vivo Concentrations of Oxygen

Baltazar D Reynafarje*
Department of Biological Chemistry, The Johns Hopkins University, USA
*Corresponding Author : Dr. Baltazar D Reynafarje
Department of Biological Chemistry
The Johns Hopkins University
410 Worthington Street
Marco Island FL 34145-5042, USA
Tel: 239-642-6370
E-mail: [email protected]
Received February 05, 2014; Accepted March 03, 2014; Published March 10, 2014
Citation: Reynafarje BD (2014) The Electromechanical Mechanism of ATP Synthesis in the Presence of In Vivo Concentrations of Oxygen. Biochem Physiol 3:128. doi:10.4172/2168-9652.1000128
Copyright: © 2014 Reynafarje BD. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

The synthesis of ATP is undoubtedly the most important phenomenon that occurs in living organisms. The following experimentally determined facts are mechanistically significant. 1) Net synthesis of ATP only occurs during the extremely fast respiratory process in which cytochrome aa3 undergoes net oxidation. 2) The hyperbolical processes of electron flow and O2 reduction to water precede the sigmoidal process of ATP synthesis. 3) The exergonic process of O2 consumption controls the level of ADP and the endergonic process of ATP synthesis, not vice versa. 4) The extent and rates of electron flow and O2 uptake are the same in the presence or absence of ADP. 5) The rates of O2 uptake and ATP synthesis are orders of magnitude higher in the presence of in vivo levels of O2 than under state-3 metabolic conditions in the presence ~230 μM O2. 6) The KM of cytochrome aa3 for O2 is close to 30 μM not below 0.5 μM. 7) The ATP/O ratio is not constant but changes from near zero to 3.4 exquisitely depending on the redox potential and the relative concentrations of cytochrome aa3, O2 and ADP. 8) Net ejection of H+ only occurs during the reduction of cytochrome aa3 and the slow phase of O2 uptake. It is concluded that the free energy responsible for the synthesis of ATP is not the protonmotive force but the structural changes that induced by the flow of electrons occur at the levels of cytochrome aa3 and ATP synthase.

Keywords

Google scholar citation report
Citations : 688

Biochemistry & Physiology: Open Access received 688 citations as per google scholar report

Indexed In
  • CAS Source Index (CASSI)
  • Index Copernicus
  • Google Scholar
  • Sherpa Romeo
  • Open J Gate
  • Genamics JournalSeek
  • Academic Keys
  • JournalTOCs
  • Ulrich's Periodicals Directory
  • Electronic Journals Library
  • RefSeek
  • Hamdard University
  • EBSCO A-Z
  • OCLC- WorldCat
  • Scholarsteer
  • SWB online catalog
  • Virtual Library of Biology (vifabio)
  • Publons
  • Euro Pub
Share This Page
add_chatinline();
Top