The Toxicological Effect on the Liver Function caused by Fecal Coliform Bacteria | OMICS International | Abstract
ISSN: 2168-9652

Biochemistry & Physiology: Open Access
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Research Article

The Toxicological Effect on the Liver Function caused by Fecal Coliform Bacteria

Zaki Al-Hasawi1, Hassan Al-Harbi2, Reem Al-Hasawi3 and Esam Al-Wesabi1,4*

1Department of Biological Sciences, Faculty of Science, King Abdul Aziz University, Jeddah, Saudi Arabia

2Poison Control and Medical Forensic Toxicology Center, Jeddah, Saudi Arabia

3Department of Chemistry Sciences, Faculty of Science and arts, King Abdul Aziz University, Rabigh, Saudi Arabia

4Al-Hodeidah University, Republic of Yemen

Corresponding Author:
Esam Al-Wesabi
Department of Biological Sciences
Faculty of Science, King Abdul Aziz University
Jeddah, Saudi Arabia
Tel: 00966 26952031
E-mail: [email protected]

Received date: August 26, 2016; Accepted date: August 26, 2016; Published date: December 15, 2016

Citation: Al-Hasawi Z, Al-Harbi H, Al-Hasawi R, Al-Wesabi E (2016) The Toxicological Effect on the Liver Function caused by Fecal Coliform Bacteria. Biochem Physiol 5:209. doi:10.4172/2168-9652.1000209

Copyright: © 2016 Al-Hasawi Z, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


This study was carried out on 80 male Swiss Webster Albino mice (MFI Strain) treated for 90 days with drinking well water contaminated with fecal coliform bacteria at four doses, control (0 colony/L), low dose (490 colonies/100 L), medium dose (1100 colonies/100 L) and high dose (2400 colonies/100 L) to test the bacterial effect on the liver functions. The animal blood plasma was tested for determination of the concentrations of the substances total proteins, glucose, creatine, bilirubin, cholesterol, triacylglycerol, high density lipoprotein, low density lipoprotein and the enzymes aspirate aminotransferase, alanine aminotransferase and alkaline phosphatase. The results indicated significant increase in the concentrations of the total proteins, lipoprotein, cholesterol, creatine and bilirubin and significant decrease in the concentration of the enzymes alanine aminotransferase, aspirate aminotransferase, alkaline phosphatase and in high density lipoprotein, triacylglycerol in the animal’s blood. The functions of the liver were affected by the toxicity resulting from the fecal coliform bacteria concentrations in the well drinking water particularly at the medium and high doses.


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