Clinical Pharmacology & Biopharmaceutics
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Plants and plant products have been used for diabetes treatment throughout the world, since ages. However, only few of them
have been validated scientifically. Recently, a large number of diverse animal models have been developed for study and better
understanding of the pathogenesis of diabetes mellitus and its treatment, and thus, new drugs have been introduced in the market.
The aim of this work is to review some in vitro and the available animal models of diabetes which have been used as tools to
investigate the mechanism of action of potential antidiabetic agents. At present, the evaluation of raw plant materials used as
traditional treatments for diabetes is not subjected to rigorous tests like conventional antidiabetic medicines; and natural products
derived from plants, have been tested in chemically induced diabetes model. The aim of this review is to designing new strategies
for novel antidiabetic drug development to treat this serious disease that represents a global public health problem.
Mohamed Eddouks is Professor at Moulay Ismail University, Morocco. After his post-doctoral fellowship at Department of Physiology, Faculty of
Medicine of Montreal, Canada, he is working for the last 12 years on medicinal plants. His contribution to this field includes 3 international books and
more than 70 peer-reviewed articles and book chapters of international repute. His is serving as editorial member of some prestigious journals. He
has been the Dean of Polydisciplinary Faculty of Errachidia from 2008 to 2012.
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