Journal of Biotechnology & Biomaterials
Open Access

Abstract

Peptic ulcer disease (PUD) encompassing gastric and duodenal ulcer is the most prevalent gastrointestinal disorder. For decades it was believed that gastrointestinal ulcerations were caused by the excessive secretion of gastric acid, but many patients presenting such ulcerations had normal acid secretion rates. Then, researchers reported that peptic ulcers were been caused by an imbalance between the aggressive factors and a number of known defense mechanisms. An estimated 15,000 deaths occur each year as a consequence of PUD. In India PUD is common. In Indian pharmaceutical industry, antacids, and antiulcer drugs share 6.2 billion rupees and occupy 4.3% of the market share. Today there are two main approaches for treating ulcer. The first deals with reducing the production of gastric acid and the second with re-enforcing gastric mucosal protection. The anti secretory and anti ulcer activity of aqueous leaf extracts of Annona squamosa and Achyranthes aspera are compared standard antiulcer drug Ranitidine and evaluated. The antioxidant activity (Lipid peroxidation inhibiting activity and Nitrous oxide scavenging activity) of the respective extracts are compared for the effects with Ascorbic acid as standard. Present study establishes antiulcer and antioxidant potential in aqueous extracts of Annona squamosa and Achyranthes aspera in Aspirin plus pyloric ligation model in Rat.

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