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Peptic ulcer disease (PUD) encompassing gastric and duodenal ulcer is the most prevalent gastrointestinal disorder. For
decades it was believed that gastrointestinal ulcerations were caused by the excessive secretion of gastric acid, but many
patients presenting such ulcerations had normal acid secretion rates. Then, researchers reported that peptic ulcers were been
caused by an imbalance between the aggressive factors and a number of known defense mechanisms. An estimated 15,000 deaths
occur each year as a consequence of PUD. In India PUD is common. In Indian pharmaceutical industry, antacids, and antiulcer
drugs share 6.2 billion rupees and occupy 4.3% of the market share.
Today there are two main approaches for treating ulcer. The first deals with reducing the production of gastric acid and the
second with re-enforcing gastric mucosal protection.
The anti secretory and anti ulcer activity of aqueous leaf extracts of Annona squamosa and Achyranthes aspera are compared
standard antiulcer drug Ranitidine and evaluated. The antioxidant activity (Lipid peroxidation inhibiting activity and Nitrous
oxide scavenging activity) of the respective extracts are compared for the effects with Ascorbic acid as standard. Present study
establishes antiulcer and antioxidant potential in aqueous extracts of Annona squamosa and Achyranthes aspera in Aspirin plus
pyloric ligation model in Rat.
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