Bacterial Metabolites For Combating Cancer | 13337
Clinical Pharmacology & Biopharmaceutics
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AGram-negative, red-pigment producing bacterial strain was isolated from an agricultural farm in Mandya district, India. It
was identified as
on the account of phenotypic and genotypic (16s rRNA sequencing) characterization.
The production of pigment was screened on different synthetic and agro waste based media. The maximum pigment production
(~40g/L) was obtained in peanut oil cake based medium. This pigment was extracted and purified by phase separation and column
chromatography. The purified pigment was analyzed by liquid chromatography - mass spectrophotometry and showed a single
peak with the expected molecular weight of 324 Da corresponding to prodigiosin. The structure of prodigiosin was further
confirmed by 1H-NMR spectroscopy. The effect of prodigiosin on the viability of acrylamide induced mouse leukemic monocyte
macrophage cells was studied. On treatment of these cells with prodigiosin, cell apoptosis and thereby a constant decrease in the
further progression of cancer was achieved. Morphological analysis of prodigiosin-treated cells by confocal microscopy revealed
that prodigiosin induces shrinkage and detachment of cells from the cell culture substrate. The purified metabolite also showed
antimicrobial activity against several pathogenic bacterial species markedly against
. Prodigiosines have recently received attention for their antibacterial and anticancerous abilities, and these results
confirm its use as a potential chemotherapeutic and antibacterial drug.
Darshan has completed his M Tech at the age of 24 years from Manipal University, India and is currently pursuing his doctoral studies from Academy
of Scientific & Innovative Research (AcSIR) at Central Food Technological Research Institute (CSIR - CFTRI), Mysore, India. He is a fellow of Council
of Scientific & Industrial Research (CSIR) -The premier industrial R&D organization in India. He has published 2 papers in reputed international
journals and is an active member of Association of Food Scientists and Technologists (AFSTI), India. He also has presented papers and won awards
in several national conferences. His specialization is in cancer biology
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