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Bioavailability And Antihyperglycemic Effect Of Metformin Transfersome Vesicles In Transdermal Patch Delivery System | 50316
ISSN: 2167-065X
Clinical Pharmacology & Biopharmaceutics
Open Access
Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.
Metformin, a prominently prescribed antihyperglycemic agent has been proven to increase life span of both diabetic and nondiabetic
individuals. It decreases glucose production and absorption and increases body’s response to insulin. However, it is
slowly and incompletely absorbed in the gastrointestinal tract and it has a low permeability. It is available in oral tablet and it takes 6
hours for the drug to be completely absorbed. It is taken 2 to 3 times a day as a maintenance drug, depending on patient’s condition.
Gastrointestinal side effects have also been reported in nearly 30% of patients. With these impediments, different drug delivery systems
have been developed. The use of transfersomes in transdermal patch offers the potential advantage of improving the bioavailability
of the drug. Metformin transfersome vesicles were prepared using sodium cholate and phosphatidylcholine 50% and its particle
size was 168 nm. Drug entrapment efficiency was determined using HPLC and it was found to be 94.96%. Plasma concentration
of metformin in hyperglycemic-induced rabbits treated with metformin transfersome patch was significantly higher than controls
(p=0.001). The post treatment glucose level of hyperglycemia-induced rabbits applied with metformin transfersome patch (p=0.002)
showed significant decrease in glucose level relative to untreated alloxan-induced hyperglycemic rabbits. The study showed that
metformin transfersome vesicles in transdermal patch delivery provide enhanced antihyperglycemic effect and bioavailability over
metformin transdermal patch.