Butanolic Fraction Of Byrsonima Verbascifolia Leaves Inhibits TNF-α And PGE2 Production: A Possible Mechanism Involved In The Anti-inflammatory Activity | 50300
ISSN: 2167-065X

Clinical Pharmacology & Biopharmaceutics
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Butanolic fraction of Byrsonima verbascifolia leaves inhibits TNF-α and PGE2 production: A possible mechanism involved in the anti-inflammatory activity

7th Annual Global Pharma Summit

Adriana Cristina Soares de Souza, Aline Aparecida Saldanha, Joao Maximo de Siqueira, Ana Hortencia Fonseca Castro, Rosy Iara Maciel de Azambuja Ribeiro, Flavio Martins de Oliveira, Debora de Oliveira Lopes, Flavia Carmo Horta Pinto and Denise Brentan Silva

Federal University of Sao Joao del-Rei, Brazil University of São Paulo, Brazil Federal University of Mato Grosso do Sul, Brazil

ScientificTracks Abstracts: Clin Pharmacol Biopharm

DOI: 10.4172/2167-065X.C1.019

Byrsonima verbascifolia (L) DC (Malpighiacea), popularly known as ‘murici’ is a plant that grows in the Brazilian Cerrado. The leaves of this species are widely used in folk medicine in the form of infusion to treat inflammatory conditions. The present study aims to evaluate the in vivo anti-inflammatory activity of the butanolic fraction of B. verbascifolia leaves (BvBF) in order to contribute to validation of the traditional use. The effect of the BvBF was assessed in carrageenan-induced paw edema in mice, an acute inflammation experimental model. Their chemical composition was characterized using liquid chromatography coupled to diode array detector and mass spectrometry (LC-DAD–MS) and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS). All doses of BvBF tested (12.50, 25 and 50 mg/kg, intraperitoneally-i.p.) clearly demonstrate significant antiedematogenic activity (p<0.001). The suppression of local edema formation by the minor dose was 84.21±2.236% and 53.84±2.582%, 2 and 4 hours after the inflammatory stimulus, respectively. Moreover, BvBF (12.50 mg/kg, i.p.) also inhibited tumor necrosis factor alpha (TNF-α) and prostaglandin E2 (PGE2) production, as well as polymorphonuclear (PMN) leucocyte recruitment to the mice footpad. Phytochemical analysis revealed the presence of the 45 compounds, including proanthocyanidins (condensed tannins), phenolic acids, flavonoids (flavones and flavonols) and other compounds. In summary, it is possible to propose that the mechanism of the anti-inflammatory action in the BvBF is linked to the decrease of pro-inflammatory mediators levels such as TNF-α and PGE2, which leads to the inhibition of the PMN leucocyte migration.

Adriana Cristina Soares de Souza has completed her Master (1999) and PhD (2004) studies from Federal University of Minas Gerais, Brazil. She was a Professor of Clinical Pharmacology at the University Center Newton Paiva from 1999 to 2009. Currently, she is teaching Pharmacology at the Federal University of São João del-Rei, Brazil. She has published 17 papers in reputed journals and has been serving as a Reviewer in the health journals. She has experience in pharmacology with emphasis on pharmacology of pain and inflammation and clinical pharmacology.

Email: [email protected]