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Combined Between-and Within Patient Response Surface Pathway Design | 23490
ISSN: 2167-065X
Clinical Pharmacology & Biopharmaceutics
Open Access
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Background: This study describes a combination of between- and within patient in a two dimensional Response Surface
Pathway (RSP) design and introduce a randomization procedure in the clinical trial. This development is exemplified by a
dose-response study of Qlice in treatment of Atlantic salmon against sea lice (salmon louse).
Methods: The study was performed as a ?between-patient? three level RSP trial in single dose finding and ?within-patient?
RSP in duration of the dose. Reduction in lice was the outcome variable. The study consisted of 15 net pens (3.6 mill. salmon
incl. control) with minimum 4 lice/fish. The study was conducted to determine the minimum efficient dose (MED) of a new
treatment procedure. Adjustment of the dose from one design level to the next and duration between treatments within net
pens was based on k-adjustment factors estimated to ensure coverage of the entire two predefined windows. Three net pens
were included on the first dose/design level, five on the second and seven on the third. In order to obtain the ?between patient?
RSP in the dose arm, a randomization procedure was introduced.
Results: The optimal dose procedure of Qlice was estimated to 8.0 mg/kg biomass distributed during a period of 2 hours and
10 minutes. This dose procedure reduced the percent lice with 83.6%. No obvious interaction between dose and duration of
dosage was detected. No adverse events were recorded.
Conclusion: Both the two dimensional RSP design and the randomization procedure used in the dose-arm worked satisfactorily
in the field.
Biography
Trond Holand graduated as a veterinarian from the Norwegian School of Veterinary Science (NVH), Oslo, Norway in 1995. Besides experience from practice as
a veterinary surgeon, he is co-founder of US based OptiNose Inc. (www.optinose.com) with strong phase III results and has 12 years experience from medical
research and contributed to 8 publications in international medical journals. He started as a PhD fellow at NVH with Prof. Stig Larsen in 2013 and will finalize his
thesis in Clinical Research Methodology in 2015.
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