Clinical Pharmacology & Biopharmaceutics
Open Access

Abstract

In this research we demonstrate that porous Fe3O4 structures can be used as a vehicle for the transport of drugs adsorbed onto their porous surface. We used methyl blue as a surrogate drug. It adsorbs onto the Fe3O4 surface and its release into the surrounding water via application of a magnetic field. Controlled release of the methyl blue to water was then achieved by application of a magnetic field. Application of a pure AC field caused released of the methyl blue. However, a combination of both DC and AC fields resulted in much faster release. This study demonstrates a concept for controlled drug delivery, where pharmaceutical molecules, similar to methyl blue, would be adsorbed onto porous Fe3O4 structure and the released at a target by application of appropriately localized magnetic fields. Furthermore, we developed super paramagnetic nanoparticles for activation of the MscL nano-valves incorporate in liposome by magnetic field. Synthesized CoFe2O4 nanoparticles were labeled by -SH groups for attachment to MscL channels. Activation of MscL by magnetic field with the nanoparticles attached was examined by the patch clamp technique showing that the number of activated channels under ramp pressure increased upon application of the magnetic field. A combination of MscL channels and the magnetic nanoparticles generated for this study holds promise for use in the development of “smart liposomes”, a new generation of liposome drug delivery system.

Biography

Email: mislav.mustapic@gmail.com