alexa Design, Formulation And In Vitro Characterization Of Irbesartan Solid Self-nanoemulsifying Drug Delivery System (S-SNEDDS) Prepared Using Spray Drying Technique
ISSN: 2167-065X

Clinical Pharmacology & Biopharmaceutics
Open Access

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4th International Pharma & Clinical Pharmacy Congress
November 07-09, 2016 Las Vegas, Nevada, USA

A R Gardouh
Suez Canal University, Egypt
Posters & Accepted Abstracts: Clin Pharmacol Biopharm
DOI: 10.4172/2167-065X.C1.023
Abstract
In this study, a novel liquid SNEDDS containing Irbesartan was formulated and further developed into a solid form by spray drying technique using Aerosil 200 as solid carrier. Results showed that the mean droplet size of all reconstituted SNEDDS was found to be in the nanometric range with optimum PDI values. All formulae also showed rapid emulsification time, good optical clarity and high drug content; and were found to be highly stable. Transmission electron microscopic images showed the formation of spherical and homogeneous droplets with a size smaller than 50 nm, which satisfies the criteria of nanometric size range required for nanoemulsifying formulae. In vitro release of IRB from SNEDDS formulae showed more than 99% of IRB release in approximately 90 minutes. Optimized SNEDDS formulae with the smallest particle size, rapid emulsification time, best optical clarity and maximum drug content and rapid in vitro release were selected to be developed into solid selfnanoemulsifying drug delivery system (S-SNEDDS) using spray drying technique. The prepared S-SNEDDS formulae were evaluated for flow properties, differential scanning calorimetry (DSC), scanning electron microscopy (SEM), reconstitution properties, drug content and in vitro dissolution study. Reconstitution properties of S-SNEDDS showed spontaneous selfnanoemulsification and no sign of phase separation. DSC thermograms revealed that IRB was in solubilized form and FTIR supported these findings. SEM photographs showed smooth uniform surface of S-SNEDDS with less aggregation. Results of the in vitro drug release showed that there was great enhancement in dissolution rate of IRB.
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