Development And Characterization Of Lidocaine Transdermal System With Self-Emulsifying Nanosystem (SENs) | 35284
Clinical Pharmacology & Biopharmaceutics
Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.
The objective of this work is to develop and characterize Nano-emulsion based transdermal system (NTS) having Lidocaine in
Nano-emulsion form. This second generation Nano-emulsion based transdermal drug delivery system has several advantages
over traditional gel and transdermal systems (TS). NTS are therapeutically more effective compared to gel and conventional
transdermal patches. Nano-emulsion components including surfactants and co-surfactants enhance skin permeability thereby
increasing therapeutic efficacy and bioavailability of the drug molecule. Moreover, the release profile can be modulated by altering
the ratio between surfactant, co-surfactant, and solvents.
Lidocaine NTS was prepared by casting Lidocaine-polymer matrix on non-woven felt with a thickness of 1.4 mil using Optimags
coating machine. Coated non-woven felt was dried at ambient temperature for 20-25 minutes till dry matrix thickness remains 1.28
mil to achieve 14 g/140 cm2 drug content per patch size. Lidocaine self-emulsifying nanosystem was prepared by dissolving Lidocaine
in surfactant, co-surfactant, lipophilic, and hydrophilic solvents then incorporated into a cross-linked super absorbent polymer
matrix containing high molecular weight cationic, anionic polymers stabilized with preservatives, chelaters, and stabilizers. The rate
of drug release, adhesiveness, stickiness, and cooling effect were controlled through a combination of polyacrylate and cross-linking
agents. Lidocaine SENS was characterized for globule size, potency, and transmittance. Furthermore, in-vitro skin permeation testing
was also carried out using a franz diffusion cell with an effective diffusional area of 0.64 cm2 and 5 ml receiver chamber capacity using
Asian (59 Male) skin.
Sridhar Gumudavelli completed his Masters at the age of 23 from Kakatiya University, India, under the eminent Prof. C.K.Kokate. He also earned a Gold Medal in Pkg. technology from IIP, India. He is the director of Product Development in Ascent Pharmaceuticals Inc., a premier generic drug development organization. He has published more than 25 papers on various scientific podiums and patented various drug delivery technologies including modified release solid and liquid dosage forms.