Clinical Pharmacology & Biopharmaceutics
Open Access

Abstract

Ubiquitin Carboxy-Terminal Hydrolase-L1 (UCH-L1) has been established as a reliable and potential biomarker of neuronal damage. There is not much information about the effects of White Matter Lesions (WMLs) on serum UCH-L1 levels in white matter disease patients. This study was aimed to assess whether serum UCH-L1 levels are a reliable marker of brain damage in patients with WMLs. Serum levels of UCH-L1 were assessed by sandwich Enzyme-Linked Immunosorbent Assay (ELISA) in 74 patients with type 2 diabetes mellitus, depression, or vascular disease. MRI was performed by a neuro-radiologist blinded to clinical data. Of these 74 patient cases, 26 showed periventricular WMLs, 22 showed subcortical WMLs, and 26 displayed no well-defined WMLs (controls). Serum UCH-L1 levels were significantly different between the two groups (p<0.05). Further sub-group analysis proved that serum UCH-L1 levels in participants with sub-cortical WMLs were significantly increased when compared with controls (p<0.001), but there was no significant differences between controls and patients with periventricular WMLs (p>0.05). These findings suggest that serum UCH-L1 levels may serve as a novel biomarker for neuronal damage from WMLs, especially sub-cortical WMLs.

Biography

Yuyuan Li has completed her PhD from the Ministry of Education Key Laboratory of Laser Life Science of South China Normal University. She is a Lecturer of Dalian Medical University. She has published more than 10 papers in reputed journals and has been serving as an Editorial Board Member of Edorium Journal of Emergency Medicine. She has been supported by National Natural Science Foundation of China, and the Educational Commission of Liaoning Province of China.

Email: liyuyuan831221@163.com