Docosahexaenoic Acid Prevents Resistance To Antiepileptic Drugs In Two Animal Models Of Drug-resistant Epilepsy | 103618
International Journal of Emergency Mental Health and Human Resilience
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Objectives: One-third of epileptic patients are resistant to antiepileptic drugs. Few clinical studies with small sample size
indicate that polyunsaturated fatty acids could control drug-resistant epilepsy. We examined the efficacy of acute and chronic
administration of docosahexaenoic acid (DHA) in two animal models of drug-resistant epilepsies, i.e. 6-Hz psychomotor
seizures in mice and lamotrigine (LTG)- resistant kindled rats.
Methods: Mice received a single injection of DHA (300 ?M, i.c.v.) along with phenytoin (PHT) or LTG (i.p.). Six-Hz electroshock
(0.2 milliseconds rectangular pulse width, 3 seconds duration, 44 mA current) was given 15 minutes after DHA, and seizure
behaviors were recorded. In LTG-resistant kindled rats, a single dose of DHA (300 ?M, i.c.v.) was administered with LTG, and
seizure parameters were measured. In chronic treatment, mice received DHA (0.1 g/day, orally) for 30 days. Then, a single
dose of LTG or PHT was administered to mice and 6-Hz-induced seizures were recorded. In rats, DHA (1 ?M, i.c.v.) was
administered during kindling development and effect of LTG in DHA-pretreated LTG-resistant kindled rats was verified.
Results: LTG and PHT did not inhibit 6-Hz seizures in mice after single injection of DHA. However, LTG and PHT inhibited
6-Hz seizures in mice that received DHA for 1 month. Acute or chronic administration of DHA to LTGresistant kindled rats
led to the suppression of kindled seizure parameters by LTG.
Discussion: DHA removes the ???inherent resistance??? of 6-Hz seizures to PHT and LTG, and prevents the development of
pharmacodynamic tolerance to LTG in LTG-resistant kindled rats. DHA might have potential to be used as add-on therapy in
patients with refractory epilepsy.
Morteza zendehdel has completed his PhD at the age of 25 years from University of Tehran and postdoctoral studies from Monash University, School of Medicine. He is academic member of University of Tehran. He has published more than 40 papers in reputed journals and has been serving as an editorial board member of Neurotransmitter Journal.