alexa Effect Of Sildenafil In The Management Of Preoperative Pulmonary Hypertension
ISSN: 2167-065X

Clinical Pharmacology & Biopharmaceutics
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

2nd International Summit on Clinical Pharmacy
December 02-03, 2014 DoubleTree by Hilton Hotel San Francisco Airport, USA

Ashraf M Eskandar
ScientificTracks Abstracts: Clinic Pharmacol Biopharm
DOI: 10.4172/2167-065X.S1.006
Abstract
Background: Pulmonary arterial hypertension (PAH) is a disabling chronic disorder of the pulmonary vasculature, which is characterized by increased pulmonary artery pressure (PAP) as a result of increased pulmonary vascular resistance (PVR). The most accepted hemodynamic definition of PH is a mean PAP >25 mmHg. It is accidentally discovered preoperatively through performing an echocardiogram in patients suspected of having PH, as these patients suffer from dyspnea which is the most frequently presenting symptom. Additional symptoms include fatigue, weakness, angina, syncope, and lower limb edema. The aim of the study was to evaluate the efficacy and safety of preoperative oral sildenafil administration in the management of pulmonary hypertensive patients scheduled for non-cardiac surgery. Patients and methods: 30 Patients, (ASA II?III), suffering from pulmonary hypertension and scheduled for non-cardiac surgery were randomly assigned to one of two groups. Group I received 25 mg sildenafil twice daily for one week before surgery. Group II received placebo in the same way. PAP, LVEF and RVEF (through echocardiogram), heart rate, mean arterial blood pressure, SpO2 (oxygen saturation), functional class and 6-min walk distance were measured and recorded at baseline and one week after treatment in both groups. Results: Sildenafil significantly reduced PAP and improved exercise tolerance, functional class, 6-min walk distance and SpO2 without significant alteration of heart rate and mean arterial blood pressure. Conclusion: The study showed effective and safe administration of preoperative oral sildenafil in the management of pulmonary hypertensive patients scheduled for non-cardiac surgery.
Biography
Ashraf Eskandar, Lecturer and Consultant of Anesthesia and Surgical Inensive Care in Menoufiya University Faculty of Medicine and Hospitals. He has completed my M.D at the age of 35 years from Menoufiya University and postdoctoral studies from Menoufiya University Faculty of Medicine. He is the director of Menoufiya University Operative Rooms. He has published more than 8 papers in reputed journals and working in the field of anesthesia and intensive care for more than 17 years.
image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version