alexa Efficacy Of Chloroquine-doxycycline Combination Therapy On Co-infection Of Malaria And Onchocerciasis In Ahani-achi
ISSN: 2476-2075

Optometry: Open Access
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World Congress and Expo on Optometry & Vision Science
July 17-19, 2017 Chicago, USA

Akujobi, A.U
Bausch & Lomb school of optometry, Algeria
Posters & Accepted Abstracts: Optom Open Access
DOI: 10.4172/2476-2075-C1-003
Abstract
The clearance rates of separate and combination therapies of chloroquine and doxycycline on malaria, onchocerciasis and mixed onchocerciasis-malaria parasitemia in 603 volunteers aged 10-60+ years were investigated for baseline and post-intervention mean parasite densities (MPD) using skin snip biopsy and smear microscopy techniques between March 2012 and April 2014. Subjects were classified into onchocerciasis (n=100), onchocerciasis+ chloroquine-doxycycline therapy (n=90), malaria (n=104) and concomitant onchocerciasis-malaria (n=309) groups. Standard treatment with doxycycline was 200mg daily dose for 6 weeks while that of chloroquine was 1000mg loading dose, followed by 500mg after 6-8 hours, then 500mg each day for 2 days. Result showed that the clearance rates of chloroquine-doxycycline, chloroquine-only and doxycycline-only on concomitant onchocerciasis-malaria parasitemia were 100%, 94.12% O. volvulus; 52.97% MP and 100% O. volvulus; 97.70% MP respectively. Chloroquine was shown to potentiate the microfilaricidal action of doxycycline. Chisquare (X2) analysis showed that the difference between the clearance rates of combination therapy and chloroquine-only therapy on concomitant onchocerciasis-malaria parasitemia was statistically significant (P<0.05) while the difference between the clearance rates of combination therapy and doxycycline-only therapy on mixed parasitemia was not statistically significant (p>0.05). In conclusion, Chloroquine-doxycycline combination therapy proved effective as a novel therapeutic strategy in the management of separate and co-infection of malaria and onchocerciasis.
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