Health-related Quality Of Life And Blood Pressure Control In Patients With Pseudoresistant Hypertension | 23500
Clinical Pharmacology & Biopharmaceutics
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The objective of this study was to examine the relationship between adherence and HRQoL in resistant and pseudoresistan
hypertensive patients.We conducted a cross-sectional study with hypertensive outpatients. Hypertensive patients were
divided into three groups: patients with controlled hypertension, patients with Resistant Hypertension (RHTN) and patients
with pseudoresistant hypertension (pRHTN). Adherence was assessed using a validated version in Portuguese of the 8-item
Morisky Medication Adherence Scale (MMAS- 8). Patient HRQoL was assessed using SF-36 survey. 183 patients were included
in the study; mean age was 55.1 years (SD 11.08) and 66.8% were female. Only 94 (51.4%) patients achieved BP control,
20 (10,5%) met criteria for RHTN and 97 (53.0%) were pseudoresistant hypertensive patients. Systolic blood pressure was
significantly higher (p <0.00) among patients with the pseudoresistant hypertension. As expected, patients with RHTN showed
lower scores for physical functioning (P = 0.04), vitality (p = 0.035) and mental health (p = 0.028), however, the subgroup
of patients with pseudoresistant hypertension due to poor medication adherence showed the worst scores in all domains of
HRQoL (p = 0000). The non-adherent behavior besides being an important cause of pseudoresistant hypertension appears to
be linked to reduced HRQoL and difficulty controlling blood pressure. The identification of such cause and contribute to the
diagnosis of pseudoresistant hypertension ,as enables the adoption of measures to improve the quality of life, especially those
that promote self-care, targeting the needs of these patients.
Sabrina Joany Felizardo Neves has completed his PhD at from Federal University of Pernambuco. She is the coordinator of pharmacy course of Federal University
of Alagoas. Conducts research in the area of clinical pharmacy and pharmacoepidemiology. She has published papers in reputed journals.
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