Clinical Pharmacology & Biopharmaceutics
Open Access

Abstract

STUDY-1: Calcium-alginate with Mn,Zn/chlorophyllinis (Trionic?) used for fibrinous-wounds-bed. One half of 7venous ulcers was treated with alginate- Mn,Zn-dressing and the other half of the same ulcer with another alginate. Results: Half of the ulcer treated with alginate-Mn,Zn-dressing showed progress in100%wheather the other half of the same ulcer treated with another alginate showed progress in only28%. STUDY-2: Evaluated the effects of two alginate-dressings on the healing and pain during the treatment of 20v.ulcers. Results: Ulcers treated with alginate/silver(Silvercel?)were smaller for15,4%and ulcers treated with calcium-alginate were larger for0,7%.Pain was smaller at the patients treated with alginate/silver(begin:severe/end:no pain)compared to ulcers treated with alginate-dressings(beggin:severe/end:moderate). STUDY-3: To compare effects on healing and need for systemic-antibiotics at the 60v.ulcers by using honey-dressing (MelMax?) and silver/charcoal-dressing (Actisorb-plus?). Results:Mean wound-size at treating with honey-dressing was28cm? at the beginning and17cm? at the end.Mean wound-size at the treating with silver/charcoal-dressing was16cm? at the begin and15cm? at the end.Because of possible risk of systemic infection on day-1 swabs were taken from wound-bed from 9 patients,only 1 needed systemic-antibiotic after 1week of therapy with honey-dressings and all 6from whom swabs were taken from other group needed systemic-antibiotics. STUDY-4: To compare effects on healing of foam-dressing with silver(Contreet-H?)versus ?local-best-practice? in the treatment of619ulcers with delayed healing. Results: Wound-area decreased faster in patient treated with foam-dressing/silver(50% vs. 34.3%reduction).The foam-dressing/silver significantly promotes positive wound progres in67%compared to51%using ?local-best-practice?. STUDY-5: Impaired wound healing in 5chronic-wounds is associated with imbalance of excessive metalloproteases and inhibitors and higher level of bacteria who disturbing granulation-tissue formation.The dressing we used composed of collagen/oxidized-regenerated-cellulose/ionically-bound-silver(Promogran-Prisma?). Results: The whole ulcers-area were reduced for average34.11%per patient in17days. STUDY-6: Comparing the hydrofibre-dressing and ointments in changing microbial-colonisation and healing of 24 v.ulcers in 7weeks. Results: The most frequently isolated bacteria in group with hydrofibre-dressings(Aquacel?)was PseudomonasAeruginosa (begin:44.4%/end:20%)in group with ointment was most frequently Pseudomonas (begin:53.3%/end:60%).Mean wound-size at treating with hydrofibre-dressing was9.6cm? at the beginning and8.8cm? at the end.Mean wound-size at the treating with ointments was16.4cm? at the begin and19.5cm? at the end. STUDY-7: To evaluated effects on healing and pain in 5v.ulcers on Atrophie-blanche with using the hydrobalance-cellulose-dressings(Suprasorb-X?). Results:The average reduction in size of individual ulcer was9.6cm? in two-weeks. Pain was before therapy average:8 and at the end 0.2per patient. STUDY-8: The chronic pain was severe in 5patients with 7v.ulcer.The poliuretain-foam-dressings with analgesics(Biatain-Ibu?)were using to evaluate pain decreased. Results: The average-reduction of pain was from:8.4 to5.4per patient at the end. STUDY-9: Comparing increase of the skins-isles inside the 27v.ulcers with using and no using non-alcohol-film-forming-skin-protectant(Cavilon-spray?). Results: The ulcers area were reduced for15.55%in the ulcers treated with non-alcohol-film-forming-skin-protector and enlarged for1,12%at the other ulcers. The isles were lagered for two-times with non-alcohol-film-forming-skin-protector and reduced for13,8%at the ulcers withouth it. STUDY-10: 5 patients with not progress in healing venous leg ulcers for 5,2 years mean. At begin were in stage C3 and size was 24,44 cm? mean. Foam AMD with PHMB? changed every 3-4 days. The treatment last mean 44,7 days or until wound did not healed. Results: One wound healed. The other were smaller and measurement at the end 17,69 cm? mean. The wound beds were in a stage A2. STUDY-11: To evaluated effects on healing and pain in 14 C2-3 VLU treating with honey (Vivmel?- group 1) and 16 C3 VLU treating with antiseptic (AMD with PHMB? - group 2). Results: In group1 were results on healing fasters (after one week), but in group 2 were no pain than there were at group1. After two weeks all the VLU from both group were B2 by Falanga 's clssification.

Biography