Clinical Pharmacology & Biopharmaceutics
Open Access

Abstract

Introduction: Ovarian hyperstimulation syndrome (OHSS) is usually iatrogenic and potentially life-threatening complication of ovulation induction. It can occur rarely following hypothyroidism. We report this syndrome in two members of a family with hypothyoidism and describe the effects of levothyroxine replacement in the management of it. Cases: A 15 years Old girl presented with abdominal pain and distention for a few months. On examination, she had classic features of hypothyroidism. Abdominal ultrasound revealed enlarged ovaries with multilobulated ovarian cysts (Right ovary: 150?75mm, volume: 454cc; Left ovary: 130?70 mm, volume: 340cc).The second patient, a 14.5 years old girl (the cousin of the patient1) presented to the emergency unit with acute abdominal pain, nausea and vomiting after a minor trauma. she had also classic features of hypothyroidism. Abdominal ultrasound revealed enlarged ovaries with multilobulated ovarian cysts(Right ovary: 110? 65 mm, volume: 279cc; Left ovary: 118? 58 mm, volume: 285cc). Both patients,started on levothyroxine 100 μg per day regarding their thyroid function test.hypothyroid features resolved and thyroid function test became normal after 2 months. Follow-up ultrasound of the first patient, showed significantly smaller ovaries after 6week and became normal with complete resolution of cysts after 4 months. The second patient who was less compliant with her treatment also showed improvement, but in longer duration. Conclusion: In OHSS associated with hypothyroidism, patients could benefit from levothyroxine replacemnet not only for treatment of hypothyroidism but also for achieving normalization of ovary size with regression of cysts within a few months.

Biography

Fatemeh.Ghazanfari Amlashi obtained her medical diploma at Guilan University of Medical Sciences in 2009; she delivered a unique thesis about the role of biomarkers in diffuse axonal injury and published it in a reputed journal. After graduation, she worked for 2 years in a rural clinic to improve her practical talents. Then, she has started collaboration with Guilan Endocrinology and Metabolic Research Center and presented one of their works in ICE/ECE 2012 as a poster. She has published one article in an omicsgroup-related journal. As a young general practitioner, she would like to pursue her studies as both medical researcher and specialist, particularly in the field of internal medicine.