alexa Molecular Targets Of B-lactams-beyond The Usual Suspects
ISSN: 2167-065X

Clinical Pharmacology & Biopharmaceutics
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4th International Pharma & Clinical Pharmacy Congress
November 07-09, 2016 Las Vegas, Nevada, USA

Monika I Konaklieva
American University, USA
Keynote: Clin Pharmacol Biopharm
DOI: 10.4172/2167-065X.C1.021
Abstract
b-Lactams have historically been viewed as a class of antimicrobials. However, this paradigm is shi ing towards a focus on their ability to function as inhibitors of bacterial enzymes, particularly those involved in broad-spectrum b-lactam resistance, i.e., extended spectrum b-lactamases (ESBL).  is shi in focus is the result of the recognition of the b-lactam’s ability to acylate enzymes, the majority of which have serine as nucleophile in the active site. In addition to being inhibitors of bacterial enzymes, b-lactams also inhibit viral and mammalian serine enzymes demonstrating inter-kingdom activity.  e focus of this presentation is on the evaluation of the potential of b-lactam antibiotics as inhibitors of the serine enzymes of both prokaryotic and eukaryotic origin, with speci c focus on the structure-function relationship of b-lactams as antimicrobial and antineoplastic agents.
Biography

Monika Konaklieva completed her PhD in Chemistry - Organic Synthesis from SUNY Buffalo -1997, and became a visiting professor in Medicinal Chemistry at Midwestern University, Chicago, Illinois (1997-1999). She is currently an Associate Professor at American University. She has published more than 40 papers in reputed journals and has been serving as an editorial board member of several chemistry journals publishing in the areas of organic and medicinal chemistry.

Email: [email protected]

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