Clinical Pharmacology & Biopharmaceutics
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The agr locus is important for virulence in a variety of animal models of infection, and has been assumed by inference to
have a major role in human infection. The effector molecule of the
system is a regulatory RNA, called RNAIII, whose
synthesis is dependent on
activation and driven by the P3 promoter of the agr system, RNAIII inhibiting peptide (RIP), is very
effective in treating severe polymicrobial infections, including drug-resistant staphylococci like MRSA, since RIP downregulates
the expression of genes involved in biofilm formation and toxin production, and upregulates genes involved in stress response.The
fact that determining virulence genes may help to differentiate no infected from infected wound is an attractive previous result
since the virulence genes of
were present significantly more in wound with grades 2-4 ulcers than grade I. So we will
explore in the paper the virulence profile, the presence and functions of
locus, clarify a possible relation between
and wound grading in cases presented with diabetic foot ulcers in our locality.
Nesrene Omar has completed her Ph.D. from Mansoura University after her scientific activities as a research associate in Molecular Virology
Dept., Baylor College Of Medicine, Houston, Texas, she is a Professor of Medical Microbiology & Immunology since 6 years and also Consultant
Infection control, with membership to local and international Society as Healthcare infection Society, attending 6 International conferences with 16
presentation and 23 local conferences with 13 presentation with the following last international publication: Novel antibiotics for the management
of diabetic foot infections, A laboratory evaluation of the antibacterial and cytotoxic effect of Liquorice when used as root canal medicament and
Nosocomial infections in neonatal intensive care units in developed and developing countries: how can we narrow the gap.
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