Clinical Pharmacology & Biopharmaceutics
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During pregnancy psychiatric disorder may occurs requiring appropriate therapy.
These conditions may also be preexisting which require careful diagnosis and
monitoring. While it is essential to treat such conditions, pregnancy limits the use of
psychotropic drugs due to potential adverse fetal outcomes and possibly teratogenicity.
Understandably improvement of the disease state may provide benefit to the
developing fetus. Recent studies show that up to 20% of women suffer from mood or
anxiety disorders during pregnancy. Depression and anxiety during pregnancy have
been associated with a variety of adverse pregnancy outcomes. Women who suffer
from psychiatric illness during pregnancy are less likely to receive adequate prenatal
care and are more likely to abuse alcohol, tobacco, and other substances known to
adversely affect pregnancy outcomes. IUGR, low birth weight and fetal growth
retardation in children born to depressed mothers have been documented. Preterm
delivery is another potential complication with an increased risk of pre-eclampsia,
operative delivery, and infant admission to a special care nursery for a variety of
conditions including respiratory distress, hypoglycemia, and prematurity. A number
of non-pharmacological options are available including cognitive behavioral and
interpersonal psychotherapy. Nevertheless a considerable percentage of patients will
need pharmacological intervention keeping in mind that a number of psychotropic
medications may treat more than one condition. This presentation covers maternal
mental illness and pregnancy outcome and current therapeutic interventions and
Bimal Roy Krishna is currently Professor and Director of Pharmacology at the College of Osteopathic Medicine, Touro University in Nevada. He obtained a Bachelor of Science (First Class Honors) in Pharmacology and Physiology and a Doctor of Philosophy, Medicine (OB/GYN/Pharmacology) from Monash University in Australia. He also teaches for the Step 1 USMLE and COMLEX reviews for Kaplan Medical throughout the United States and in UAE, Europe, Saudi Arabia, India, Mexico and the Caribbean. He has been teaching online for Kaplan University for over seven years. He has contributed to numerous publications and is a Member of a number of organizations including Fellow-American College of Clinical Pharmacology. His research background is in Maternal and Neonatal Pharmacology, specifically looking at materno-fetal transfer utilizing the perfused human placental and cultured syncytiotrophoblast model. Complementary and Alternative Medicine is another area of his interest.