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Purpose: The aim of this study was to determine the normative data of macular thickness in the Egyptian population and to
assess the effect of different demographic data and ocular parameters on it using spectral-domain optical coherence tomography
Patients & Methods: This cross-sectional study included 105 healthy Egyptian patients, who underwent a comprehensive
ophthalmic examination, including Spectralis SD-OCT scanning, at Alexandria Main University Hospital. One eye from each
patient was chosen randomly to be included in the study. Macular thickness was calculated based on center thickness and
nine areas that corresponded to the Early Treatment Diabetes Retinopathy Study map using OCT mapping software. The
relationships between macular thickness and sex, age, axial length (AL), spherical equivalent, keratometry readings, intraocular
pressure, BMI, parity, and use of oral contraceptive pills were analyzed.
Results: The study included 49 male and 56 female patients. The mean age of the patients was 40.41±14.17 years. The mean
central subfield thickness was 262.70±19.64 μm. The mean macular thickness values in all areas of the Early Treatment Diabetes
Retinopathy Study map were significantly greater in men than in women. As age increased, outer macular thickness decreased
significantly in the overall group and in female, but not in male patients (partial correlation). The AL correlated negatively with
inner and outer macular thickness (partial correlation). However, spherical equivalent had no significant influence on multiple
linear regression analysis. Central subfield thickness did not correlate significantly with keratometry readings, intraocular
pressure, BMI, parity, or use of oral contraceptive pill.
Conclusion: The mean macular thickness values in the Egyptian population were found to be less than those seen in the
Spectralis SD-OCT studies published previously on Caucasians, but more than those seen in Blacks. Sex had the most significant
effect on macular thickness in all regions. Age and AL showed a significant negative correlation with outer macular thickness.
Faculty of Ophthalmology at Alexandria University, Egypt.