Dersleri yüzünden oldukça stresli bir ruh haline sikiş hikayeleri bürünüp özel matematik dersinden önce rahatlayabilmek için amatör pornolar kendisini yatak odasına kapatan genç adam telefonundan porno resimleri açtığı porno filmini keyifle seyir ederek yatağını mobil porno okşar ruh dinlendirici olduğunu iddia ettikleri özel sex resim bir masaj salonunda çalışan genç masör hem sağlık hem de huzur sikiş için gelip masaj yaptıracak olan kadını gördüğünde porn nutku tutulur tüm gün boyu seksi lezbiyenleri sikiş dikizleyerek onları en savunmasız anlarında fotoğraflayan azılı erkek lavaboya geçerek fotoğraflara bakıp koca yarağını keyifle okşamaya başlar
GET THE APP
Synthesis, Evaluation And Docking Studies Of Some Novel 1,2,4-triazine Derivatives Bearing Five Member Heterocyclic Moiety As Potential Anti-inflammatory And Analgesic Agents | 37498
Clinical Pharmacology & Biopharmaceutics
Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.
A group of 5-substituted 1,3,4-oxadiazole/thiadiazole and 1,2,4-triazole tethered to a 5,6-diphenyl-1,2,4-triazin-3(2H)-ones were
synthesized following a “hybrid-pharmacophore” approach and evaluated for anti-inflammatory and analgesic activity. The
structure of the novel compounds were supported by FT-IR, 1H-NMR, 13C-NMR and elemental analysis. The derivatives (3a-3e, 4a-
4e and 5a-5e) were initially screened for in vitro anti-inflammatory potential by albumin denaturation assay. Compounds exhibiting
comparable activity to standard drugs indomethacin and celecoxib were further assessed in vivo for anti-inflammatory, analgesic,
ulcerogenic and lipid peroxidation activities.
Of the fifteen synthesized derivatives, six compounds namely 3c, 3d, 3e, 4c, 4d and 4e exhibited superior anti-inflammatory
activity in the acute, sub-chronic and chronic models of inflammation along with significant analgesic activity together with
negligible ulcerogenic potential. These derivatives also exhibited reduced Malondialdehyde (MDA) content suggesting their
protective effects to the inhibition of lipid peroxidation in the gastric mucosa. Derivatives 3c, 3d, 3e, 4c, 4d and 4e were found
to be potent competitive COX-2 inhibitors with IC50 range of 2.28-3.17 μM. The binding modes of these active compounds
into the COX-2 binding site through docking studies exemplified their consensual interaction and subsequent inhibition of
enzyme thus corroborating the outcomes of in vitro and in vivo biological evaluation. Outcome of the following study involving
“hybrids” embedded with two biologically active scaffolds may be further utilized for designing novel derivatives with potential
anti-inflammatory and analgesic properties with superior safety profile than the current available therapeutic medication.
Anupam G Banerjee is currently pursuing PhD in Pharmaceutical Chemistry at the Department Pharmaceutics, Indian Institute of Technology (Banaras Hindu University), Varanasi (India). His research involves the Computer Aided Drug Design based synthesis of novel heterocyclic motifs as potential anti-inflammmatory and analgesic agents. His primary research interest lies in the development of NCE’s (New Chemical Entities) possessing anti-inflammatory potential. Apart from this, he also pursues his research interest in neuropharmacology by exploring new strategies for the synthesis of NCE’s as anti-convulsants. He has published 10 research papers in various journals of international repute.