Targeting Sphingosine Kinase 1 And Apoptosis By Metformin To Decrease Tumor Resistance To Adriamycin | 37438
Clinical Pharmacology & Biopharmaceutics
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Solid Ehrlich carcinoma is a transplantable tumor model used in tumor studies. Adriamycin is a cytotoxic anthracycline antibiotic
used in treatment of many types of cancer. Metformin is anti-diabetic drug and is under investigation for treatment of cancer. The
aim of this work was to study the effect of each of adriamycin and metformin alone and in combination on solid Ehrlich tumor in mice.
One hundred albino mice were divided into five equal groups: Control untreated group, SEC, SEC+adriamycin, SEC+metformin,
SEC+adriamycin+metformin. Tumor volume, survival rate, tissue catalase, tissue reduced glutathione, tissue malondialdehyde, tissue
sphingosine kinase 1 activity, tissue caspase 3 activity and tissue tumor necrosis factor alpha were determined. A part of the tumor
was examined for histo-pathological and immune-histochemical study. Adriamycin or metformin alone or in combination induced
significant increase in the survival rate, tissue catalase, reduced glutathione and tissue caspase 3 activity with significant decrease
in tumor volume, tissue malondialdehyde, tissue sphingosine kinase 1 activity and tumor necrosis factor alpha and alleviated the
histopathological changes with significant increase in p53 expression and apoptotic index compared to SEC group. The combination
of adriamycin and metformin has a better effect than each of adriamycin or metformin alone against transplantable tumor model in
Ahmed M Kabel had the PhD degree in Pharmacology in 2013 from Faculty of Medicine, Tanta University, Egypt. He is involved in teaching undergraduate and postgraduate students as well as supervised one master student and one PhD student in Egypt. He has published more than 21 research articles in reputable international peer reviewed journals. His areas of research interests are pharmacy practice, oncology and pediatric pharmacology.