Testing The Two-hit Hypothesis Of Alzheimer Disease: Cell Cycle Re-entry | 13252
Clinical Pharmacology & Biopharmaceutics
Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.
The two-hit hypothesis of Alzheimer suggests cell cycle entry is a major factor in driving neuronal death in
Alzheimer?s disease (AD). We experimentally addressed this issue by driving c-myc expression specifically
in neurons with an inducible cam-kinase promoter. We confirmed that c-myc was specifically inducible in large
cortical/hippocampal neurons. We found expression of c-myc led to histone phosphorylation, DNA fragmentation
(TUNEL), gliosis, and neuronal death. The effects were specific to brain areas of increased expression and did not
involve the cerebellum. Consistent with neuronal specificity, behavior analysis showed the deficits were cognitive
rather than motor function. These findings support cell cycle re-entry as a critical hit of the two-hit hypothesis of
AD and point to the attractiveness of intervention to modify neuronal cell cycle re-entry as a therapeutic target.
George Perry is Dean of the College of Sciences and Professor of Biology at The University of Texas at San Antonio, and Adjunct
Professor of Pathology and Neurosciences at Case Western Reserve University. Perry is recognized in the field of Alzheimer?s disease
research particularly for his work on oxidative metabolism. He is distinguished as one of the top Alzheimer?s disease researchers with
over 1000 publications, and one of the top 100 most-cited scien
tists in neuroscience and behavior. He is editor-in-chief for the Journal
of Alzheimer's Disease, a Fellow of the American Association for the Advancement of Sciences, the Microscopy Society of America,
the Royal Society of Chemistry, and past president of the American Association of Neuropathologists, as well as a member of the Dana
Alliance for Brain Initiatives and a Fulbright Senior Specialist. Perry's research is primarily focused on how Alzheimer disease develops
and the physiological consequences of the disease at a cellular level.
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals