The Evaluation Of Renoprotective Effect Of L-Carnitine Against Gentamicin Nephrotoxicity | 23457
Clinical Pharmacology & Biopharmaceutics
Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.
The protective effect of L-Carnitine on the gentamicin nephrotoxicity was investigated in experimental animal model. Male
Wister 200-300 g rats were distributed randomly into four groups, control group, L-Carnitine treated group, Gentamicin
treated group, and L-Carnitine + Gentamicin treated group. The result showed that gentamicin nephrotoxicity in rats is
detected by significant plasma creatinine, urea and zinc changes in serum and renal tissue. L-Carnitine is able to ameliorate
the renal functions and restore the zinc status. Zinc serum level in the gentamicin treated group is 115 μg/dl, while it is 129 μg/
dl in the Gentamicin + L-Carnitine treated group, and Zinc tissue level in the Gentamicin treated group is 14.6 μg/dl, while
it is 17.89 μg/dl in the Gentamicin + L-Carnitine treated group. The possibility of scavenging property of L-Carnitine against
peroxy radical is via restoring zinc status implicated.
Sabah Akrawi, PhD, graduated from the College of Pharmacy/University of Kentucky/USA. He is an Assoc. Prof. of Clinical Pharmacokinetic and Biopharmaceutic
and a faculty member at the College of Clinical Pharmacy/King Faisal University/KSA. He supervised 17 postgraduate pharmacy students, and has published more
than 24 articles. He is a member of the scientific council of the KFU and chaired many defense committees for graduation of graduate students.
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals