Reach Us +44-3308187254


Dersleri yüzünden oldukça stresli bir ruh haline sikiş hikayeleri bürünüp özel matematik dersinden önce rahatlayabilmek için amatör pornolar kendisini yatak odasına kapatan genç adam telefonundan porno resimleri açtığı porno filmini keyifle seyir ederek yatağını mobil porno okşar ruh dinlendirici olduğunu iddia ettikleri özel sex resim bir masaj salonunda çalışan genç masör hem sağlık hem de huzur sikiş için gelip masaj yaptıracak olan kadını gördüğünde porn nutku tutulur tüm gün boyu seksi lezbiyenleri sikiş dikizleyerek onları en savunmasız anlarında fotoğraflayan azılı erkek lavaboya geçerek fotoğraflara bakıp koca yarağını keyifle okşamaya başlar
The Rational Use Of Mucolityc Drugs In Children And Worsening Of The Cough As Adverse Drug Reactions After Carbocysteine In Children | 13280
ISSN: 2167-065X

Clinical Pharmacology & Biopharmaceutics
Open Access

Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

The rational use of mucolityc drugs in children and worsening of the cough as adverse drug reactions after carbocysteine in children

International Summit on Clinical Pharmacy & Dispensing

Ioan Magyar, Alina Maghiar, Barbu Cuparencu, Mihai Botea, Carmen Pantis and Razvan Dorcu

ScientificTracks Abstracts: Clinic Pharmacol Biopharmaceut

DOI: 10.4172/2167-065X.S1.002

Introduction: Carbocysteine is a mucolytic drug similar to acetylcysteine regard to clinical uses. Carbocysteine is widely used in children with respiratory diseases such as bronchitis, pneumonia and other diseases in which the viscous and sticky mucus secretion is present. Annually, in the paediatric emergency department (EDP) are evaluated, investigated and treated on average 24 000 children aged from a couple of weeks up to 18 years. Materials and Methods: This study started from the observation that many children who received carbocysteine on arrival in EDP presented a worsening cough and even bronchospasm. We believe these symptoms are carbocysteine adverse drug reactions (ADRs). It is a retrospective study on 192 children who had various respiratory diseases. The special paper was used for the recorder of ADRs, a paper provided by Pharmacovigilance Department. Children were divided into two groups: group A (89 subjects) - who received carbocysteine and group B (103 subjects) - who have not received carbocysteine. The data were processed statistically using chi square test ( χ 2 ). Results: The most common symptom was cough in both groups (93.26% and 88.35%), followed by fever (65.17% and 65.05%) and rhinoreea (22.47% and 20.39 %). The most common combination of symptoms was cough + fever + rhinoreea (22.47% in group A and 20.39% in group B). In both groups prevailed the productive cough (46.99% and 45.05%). Dry cough and spastic cough was found in 21.69% and 12.05% in group A, respectively, 18.68% and 14.29% in group B. Conclusions: It could be, this drug has an irritating effect on the airways, thus, it should be used with caution in children. In all cases of worsening cough, this effect was associated with carbocysteine. Also, the use for a few days of carbocysteine was associated with the development of wheezing and bronchospasm. In cases of asthma, recurrent wheezing or other similar diseases the use of carbocysteine should be avoided.
Ioan Magyar has completed his Ph.D. at the age of 43 years from University of Oradea. A several postdoctoral studies (organized by British Pharmacological Society) was carried out in London UK. These workshops include Enzymes as Drug Targets (2011) and Drug Discovery (2012). He is head of Department of Pharmacology, University of Oradea and he is also involved in clinical medicine (emergency medicine). He has published about 50 papers (some of them in Romanian and others in English).