Clinical Pharmacology & Biopharmaceutics
Open Access

Abstract

Solution Plasma Process (SPP) is a physical method used for generation of nanomaterials in general and biomaterials in particular. We elaborated utilization of chitosan as matrix of nano-biocomposites using SPP. Polymer-silver nanoparticles biocomposites were synthesized by discharging plasma using a pulsed unipolar power supply into solutions of selected and AgNO3. 3D scaffolds of the biocomposites were prepared by lyophilization and cross-linked by UV irradiation. Synthesis and microstructures of the biocomposites were characterized using UV-Vis spectroscopy, FTIR, FE-SEM equipped with EDS and TEM analysis. The biocomposites showed anti-oxidant activity and also showed anti-microbial activity against various pathogens with much lower inhibitory concentration. The results also proved much more effective anti-microbial activity of the nano-biocomposites. Therefore, the silver nano-biocomposites synthesized by one-step eco-friendly SPP have potential application as topical anti-microbial agents in the modern medicine. SPP method can also be utilized as degradation of polymers such as bioavailability of effective materials with anticipated molecular weights and sizes could be also achieved by SPP. High molecular weight was degraded into LMW for biomaterial application such as DDS by discharging plasma using a pulsed power supply into polymer solution. Color changes, viscosity, pH, degradation percentage. Quantitative and qualitative assays were performed to characterize polymer degradation using gel permeation chromatography, zeta potential analysis, dynamic light scattering and FTIR and UV-Vis spectroscopy. SPP is an inevitable and novel approach in nanopharmaceuticals and polymers adoptable for facile, reliable, economic, and eco-friendly production of desirable, pure, and stable materials for potential applications in nano-medicine.

Biography

Email: mubinano@gmail.com