alexa Abstract | The Role of Sulforaphane on Duchenne Muscular Dystrophy by Activation of Nrf2
ISSN: 2381-8727

International Journal of Inflammation, Cancer and Integrative Therapy
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Abstract

Sulforaphane (SFN) possesses powerful chemo-preventive effects and plays a crucial role on oxidative stress and inflammatory. In our recent study, SFN treatment could relieve muscular dystrophy in mdx mice by activating Nrf2 (NF-E2 related factor 2). Moreover, our findings indicated that SFN-activated Nrf2 alleviated muscle inflammation in dystrophin-deficient mdx mice through suppressing NF-κB signaling pathway. Collectively, SFNinduced Nrf2 molecular pathway might be a promising approach for treatment of the patients with Duchenne muscular dystrophy.

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Author(s): Cheng-Cao Sun, Jing-Yu Pan, Shu-Jun Li and De-Jia Li*

Keywords

Sulforaphane, Duchenne muscular dystrophy, Nrf2, Inflammation, Inflammatory Response, Inflammation, Immunity, Microinflammation and Renal Diseases

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