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Dr. William Durante is a Professor of Medical Pharmacology and Physiology at the University of Missouri.Prior to joining the University of Missouri in 2006, he was an Associate Professor in the Department of Medicine at Baylor College of Medicine. Dr. Durante obtained his PhD in Pharmacology from the University of Toronto in 1989 and then completed his postdoctoral training in the Department of Medicine at Baylor College of Medicine.
Our research focuses on understanding the biology of endogenously derived gases in the circulation. We are particularly interested in determining the regulation and function of nitric oxide (NO) and carbon monoxide (CO) in vascular disease. We have identified cationic amino acid transporters (CATs) and arginase in vascular cells and found that both proteins regulate vascular NO release by affecting the intracellular levels of L-arginine: CATs control the entry of L-arginine into vascular cells while arginase promotes the intracellular catabolism of L-arginine to L-ornithine and urea. Ongoing studies are examining whether alterations in CAT and arginase activity contribute to vascular dysfunction in diabetes and atherosclerosis. We recently discovered that vascular cells generate CO from the catabolism of heme by the enzyme heme oxygenase-1 (HO-1). Interestingly, numerous pathologic stimuli induce HO-1 gene expression and CO formation, which function in an adaptive manner to limit vascular injury. We are now attempting to identify the specific transcription factors and regulatory elements in the HO-1 promoter responsible for the induction of HO-1. In addition, we are using adenoviral-mediated gene delivery approaches and HO-1-deficient mice to further define the vasoprotective role of the HO-1/CO system. A final line of investigation focuses on defining the signal transduction pathways that trigger the release of NO and CO following the exposure of vascular cells to physiologically relevant hemodynamic forces.
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