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Sean Ekins | OMICS International
ISSN: 2167-065X

Clinical Pharmacology & Biopharmaceutics
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Sean Ekins

USA
Publications

Propranolol and Structurally Novel Derivatives as Positive Allosteric Modulators of the Alpha-7-nicotinic Acetylcholine Receptor

Purpose: Alpha-7-nicotinic acetylcholine receptor (α7-nAChR) positive allosteric modulators (PAMs) are a potential disease modifying treatment for Alzheimer’s disease, as exemplified by the approved drug galantamine. However, clinical development of this class of compounds has stalled due to poor efficacy and severe adverse reactions, li... Read More»

Aaron McMurtray, Erin Saito, Shannon Tsang, Anna Lee and Sean Ekins

: Clin Pharmacol Biopharm 2020, 9:1

10.4172/2167-065X.1000192

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