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Yutaka Osawa

USA
Publications

Pharmacokinetics of Recombinant Soluble Human Thrombomodulin in Subjects with Normal and Various Impaired Renal Function

Background: Non-clinical and clinical studies showed efficacy of thrombomodulin alfa for disseminated intravascular coagulation, and its potential efficacy for severe sepsis and coagulopathy. Thrombomodulin alfa is excreted primarily via the kidney and renal function is known to affect the clearance. However the dosing adjustments for patie... Read More»

Shinichiro Shirae, Yutaka Osawa, Thomas C Marbury and Kazuhisa Tsuruta

Research Article: Clin Pharmacol Biopharm 2016, 5:159

DOI: 10.4172/2167-065X.1000159

Abstract Peer-reviewed Full Article Peer-reviewed Article PDF Mobile Full Article

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