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He is Having deep interest in the study of science I took biology as a field of study in the under graduation and graduation level. Then I worked for three years in a clinical reference lab. During employment I realized that I wanted to be a scientific researcher. The knowledge gained in molecular biology both in theoretical and technical from the academia and industry brought great opportunity to accomplish doctorate of philosophy in medical science. During my PhD studies in Uppsala University, Sweden at Professor Bryndis Birnir’s lab, I investigated the role of neurotransmitters, GABA and its channels in immune cells. My Ph.D. thesis focused on systematic study of GABA and GABAA channels regulate immune cell functions in autoimmune disease models by using immunological, molecular biological and electrophysiology methods. My studies showed GABAA currents in native immune cell and also showed GABA decreases the proliferation of T-lymphocytes in contrast it is required to maintain progenitor proliferation. All through my Ph.D., I discovered ion channel functions and fascinated with the technology to explore the functions of ion channel I decided to join in Dr. Bimal Desai’s lab for postdoctoral training in the University of Virginia. As a postdoctoral associate, I am studying the role of ion channels and Ca+2 signaling in immunity and inflammation of native immune cells. In specific project aim for a study the role of member of TRP family ion channel regulates autoimmune disease through a specific subset of T lymphocytes.
His PhD research aimed to study GABAA ion channels importance in immune cells of auto immune diseases, Toxoplasmosis and hippocampus. Autoimmune diseases are one of the most prevalent in the world. In 2002 NIH estimated that 22 millions of Americans (8% of population) are suffered from autoimmune disorders. In these diseases immune cells attack body’s own organs, tissue and cells. As an author or co-author, in this study which leads to 3 publications we found that GABA can be used as a drug to modulate auto immune disease such as multiple sclerosis and type1 diabetes by decreasing activated T cells. And also found clues to develop specific drugs against GABA channels in T cells due to the presence of different ion channel composition in humans, rats and mice in T-cells. In another study, Toxoplasma gondii infection is prevalent between 30-50% of the world population. The parasite gets contract with the feces of domestic cats. People with immune incompetent system the infection of this parasite is fatal and in fetuses. We studied the role of GABA system in Toxoplasma gondii infected dendritic cells. In this study we showed the GABA inhibitor drugs decreases the propagation of Toxoplasmosis which is helpful for pregnant women and less immune competent system people. It is known that cognitive abilities are decreased in diseases such Alzheimer disease, diabetes mellitus and dementia comprises majority of global population. In my research we showed that a subtype of GABAA channel in the hippocampus is activated by insulin that may useful to rescue cognitive abilities
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