alexa Xiaorui Shi | Peking Union Medical College
ISSN: 2161-119X

Otolaryngology: Open Access
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Xiaorui Shi

Xiaorui Shi Xiaorui Shi
Associate Professor
Chinese Academy of Medical Sciences
Peking Union Medical College
China
Biography

Dr. Shi joined the Oregon Hearing Research Center at Oregon Health & Science University in 1999, and is currently Associate Professor of Otolaryngology. Dr. Shi has a joint appointment at Jiao Tong University, Shanghai, China, as Professor in the Institute of Hearing Research, Shanghai and is Vice Director of the Institute of Microcirculation, CAMS & PUMC, Beijing. She earned her Ph.D. at Henan Medical University and PLA Hospital, Beijing in 1997 after completing her master’s work at Shanghai Second Medical University. In 1999 she began her postdoctoral training in auditory physiology, specializing in cochlear blood flow, at the Oregon Hearing Research Center.

Research Interest

Disturbances in cochlear blood flow contribute to many clinical hearing conditions. Dr. Shi’s laboratory has three primary areas of research: (1) Physiology of inner ear blood flow, (2) Molecular mechanisms underlying noise-induced hearing loss, and (3) Clinical & translational research. Noise-induced hearing loss, with accompanying tinnitus and sound hypersensitivity, is a common condition which leads to communication problems and social isolation. The goal of the laboratory is to understand the molecular mechanisms well enough to mitigate the damage from exposure to loud sound. Free radicals and inflammatory cytokines are the proximate cause, and antioxidants and anti-inflammatory drugs have been shown to be effective in protecting the inner ear. Her laboratory has established a number of international collaborations for further clinical study including various antioxidants. 

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