Alzheimers Disease: The Novel Finding of Intracellular Biofilms
Herbert B Allen*, Rina Allawh, Andrew Touati, Christos Katsetos and Suresh G Joshi
Department of Dermatology, Drexel University College of Medicine, Philadelphia, USA
- *Corresponding Author:
- Herbert B Allen
Department of Dermatology, Drexel University College of Medicine
219 N. Broad St, 4th floor, Philadelphia, PA 19107, USA
E-mail: [email protected]
Received Date: March 28, 2017; Accepted Date: May 10, 2017; Published Date: May 12, 2017
Citation: Allen HB, Allawh R, Touati A, Katsetos C, Joshi SG (2017) Alzheimer’s Disease: The Novel Finding of Intracellular Biofilms. J Neuroinfect Dis 8:247. doi: 10.4172/2314-7326.1000247
Copyright: © 2017 Allen HB, et al. This is an open-access article distributed under the terms of the creative commons attribution license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
We previously have found biofilms in the hippocampi of Alzheimer’s disease (AD) post mortem brain specimens. We had seen them in an extracellular location and noted them to be present in the areas of pathological plaque formation. Other investigators have found the presence of spirochetes (Lyme and dental) in affected (AD) brains, and these have been correlated with Treponema pallidum. In a recent historical comparison of the pathology of syphilis, the histological findings of syphilis and AD were shown to be exactly the same. Further, spirochetes have been cultured from the affected brains and have been found to make biofilms and beta amyloid precursor protein. Utilizing the same pathological methods as in our prior study, we have found biofilms in an intracellular location. The similarity of this finding to other diseases has been presented; and, the impact of the “intra” versus the “extra” cellular location is discussed.