alexa Aqueous and Methanolic Extracts of Palm Date Seeds and
ISSN: 2168-9652

Biochemistry & Physiology: Open Access
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Review Article

Aqueous and Methanolic Extracts of Palm Date Seeds and Fruits (Phoenix dactylifera) Protects against Diabetic Nephropathy in Type II Diabetic Rats

Amani MD El-Mousalamy1, Abdel Aziz M Hussein2*, Seham A Mahmoud1, Azza Abdelaziz3 and Gehan Shaker2

1Organic Chemistry Department, Faculty of Science, Zagazig University, Zagazig, Egypt

2Physiology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt

3Pathology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt

*Corresponding Author:
Abdel-Aziz M Hussein, (PhD)
Assistant Professor of Medical Physiology, Physiology Department
Faculty of Medicine, Mansoura University, Mansoura, PO 35516, Egypt
Tel: +201002421140
E-mail: [email protected]; [email protected]

Received date: April 20, 2016; Accepted date: May 26, 2016; Published date: June 02, 2016

Citation: El-Mousalamy AMD, Hussein AAM, Mahmoud SA, Abdelaziz A, Shaker G (2016) Aqueous and Methanolic Extracts of Palm Date Seeds and Fruits (Phoenix dactylifera) Protects against Diabetic Nephropathy in Type II Diabetic Rats. Biochem Physiol 5:205. doi: 10.4172/2168-9652.1000205

Copyright: © 2016 El-Mousalamy AMD, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Objective: The present study examined the effects of aqueous and methanolic extracts of palm dates (fruits and seeds) on diabetic nephropathy in a rat model of type 2 DM. Methods: Sixty male albino rats subdivided into a) normal control (NC) group, b) diabetic control (DM) group, c) aqueous fruit extract (AFE) group, d) methanolic fruit extract (MFE) group, e) aqueous seed extract (ASE) group and f) methanolic seed extract (ASE) group. Treatment with both extracts done for 15 weeks after induction of type 2 DM. by the end of experiment fasting blood glucose, serum lipid profile, creatinine, urea, uric acid, urinary albumin excretion, kidney tissue MDA, catalase, SOD, GSH were measured and kidney histopathological examination was done. Results: Diabetic untreated rats showed significant hyperglycemia and hyperlipidemia and deterioration in kidney functions and morphology with enhanced oxidative stress in kidney tissues. On other hand, rats treated with either aqueous or methanolic fruit or seed extracts showed significant improvement in all studied parameters compared to DM group (p<0.05). However, the effects of fruit extracts especially aqueous extract were more powerful than seed extracts. Conclusion: Aqueous and methanolic fruit and seed extracts of palm date protect kidneys from diabetic nephropathy in rats which might be due to their antioxidant properties.


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