Bone Health in Metabolic Endotoxemia Related ObesityAliya IS1, Norhazilah M1, Faruk RM1, Amanov M1, Mariam IU1, Zainab M3, Gotam K2, Nordin S1 and Atif AB1*
- Corresponding Author:
- Atif AB
Faculty of Medicine
Universiti Sultan Zainal Abidin
E-mail: [email protected]
Received date: February 05, 2015; Accepted date: April 28, 2015; Published date: April 30, 2015
Citation: Aliya IS, Norhazilah M, Faruk RM, Amanov M, Mariam IU, et al. (2015) Bone Health in Metabolic Endotoxemia Related Obesity. Interdiscip J Microinflammation 3:129. doi:10.4172/2381-8727.1000129
Copyright: © 2015 Atif AB, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Obesity is a multifactorial disorder leading to multiple metabolic complications including hypertension, hypercholesterolemia, atherosclerosis, insulin resistance, type II diabetes and fatty liver. Recent research has discovered that obesity is associated with systemic low grade inflammation and one of the contributing factors can be alteration of gut microbiota due to change in dietary habits; attributed to high fat and carbohydrate diet. This altered microbiota brings along circulating lipopolysaccharide (LPS) which plays a key role in initiating low grade inflammation in adiposity associated with release of certain cytokines such as tumor necrosis factor (TNF) and interleukins especially interleukin1 (IL1) and marked by high C reactive protein, haptoglobulin alpha 1 acid glycoprotein (AAG) and alpha 1 antitrypsin (AAT) . In in this review we have focused on mechanism through which metabolic endotoxemia due to altered gut microbiome in obesity can also affect bone health and hinder bone formation. In addition to this exploring th possibility that increased leptin and decreased Vitamin D in obesity may supplement the bone loss.