alexa Contrast-Enhancing Lesions within the Spinal Chord Suggests Immune Reconstitution Inflammatory Syndrome (IRIS) in a Patient with Natalizumab Associated Progressive Multifocal Leukencephalopathy (Natalizumab-PML) | Abstract
E-ISSN: 2314-7326
P-ISSN: 2314-7334

Journal of Neuroinfectious Diseases
Open Access

Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Case Report

Contrast-Enhancing Lesions within the Spinal Chord Suggests Immune Reconstitution Inflammatory Syndrome (IRIS) in a Patient with Natalizumab Associated Progressive Multifocal Leukencephalopathy (Natalizumab-PML)

Justus Carl Marquetand*, Felix Bischof and Thomas Nägele
Center for Neurology Hertie Institute for Clinical Brain Research Department Cellular Neurology, Germany
Corresponding Author : Justus Carl Marquetand
Center for Neurology Hertie Institute for
Clinical Brain Research Department Cellular Neurology
Otfried-Müller-Straße 27 72076 Tubingen, Germany
Tel: +497071/290
E-mail: [email protected]
Received April 17, 2015; Accepted June 15, 2015; Published June 18, 2015
Citation: Marquetand JC, Bischof F, Nägele T (2015) Contrast-Enhancing Lesions within the Spinal Chord Suggests Immune Reconstitution Inflammatory Syndrome (IRIS) in a Patient with Natalizumab Associated Progressive Multifocal Leukencephalopathy (Natalizumab-PML). J Neuroinfect Dis S1:001. doi:10.4172/2314-7326.S1-001
Copyright: © 2015 Marquetand JC, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Related article at Pubmed, Scholar Google

Abstract

Background: Many patients with natalizumab-associated progressive multifocal leukoencephalopathy (PML) who are treated by plasma exchange (PLEX) develop an immune reconstitution inflammatory syndrome (IRIS), which often leads to severe tissue destruction within the brain. While steroids can efficiently treat IRIS, they worsen PML and a reliable and prompt diagnosis of IRIS in natalizumab-PML patients is thus critical.

Clinical presentation: We report on a patient with supratentorial manifestations of natalizumab-PML after PLEX and corresponding new gadolinium-enhancing lesions within the spinal cord, which were clinically corresponding to difficulties to urinate.

Conclusion: Cerebral MRI supported the diagnosis of IRIS. Therefore, detection of contrast-enhancing lesions within the spinal cord may indicate IRIS in patients with natalizumab-PML.

Keywords

Recommended Conferences
Share This Page
Top