alexa Cyclin D1 G870A Polymorphism is Associated with an Increased Risk of Simple Endometrial Hyperplasia in Egyptian Women | OMICS International | Abstract
ISSN: 2168-9652

Biochemistry & Physiology: Open Access
Open Access

Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Cyclin D1 G870A Polymorphism is Associated with an Increased Risk of Simple Endometrial Hyperplasia in Egyptian Women

Abdel Aziz A F1*, El-Refaeey A A2, Afaf M Elsaeid3 and Manar Refaat1
1Biochemistry Division, Department of Chemistry, Faculty of Science, Mansoura University, Egypt
2Department of Obstetrics and Gynecology, Faculty of Medicine, Mansoura University, Egypt
3Genetic Unit, Department of Pediatrics, Faculty of medicine, Mansoura University, Mansoura, Egypt
*Corresponding Author : Abdel-Aziz Mohammed A F
Professor/Consultant of Biochemistry
Faculty of Science, Mansoura University, Mansoura, Egypt
Tel: +201008764445 / 20502223380
E-mail: [email protected] or [email protected]
Received December 15, 2013; Accepted January 27, 2014; Published January 31, 2014
Citation: Abdel Aziz AF, El-RefaeeyAA, Elsaeid AM, Refaat M (2014) Cyclin D1 G870A Polymorphism is Associated with an Increased Risk of Simple Endometrial Hyperplasia in Egyptian Women. Biochem Physiol 3:123. doi:10.4172/2168- 9652.1000123
Copyright: © 2014 Abdel Aziz AF, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Endometrial hyperplasia (EH) is a common diagnosis in women presenting with abnormal uterine bleeding, leading to cancer if untreated. Cyclin D1 A870G polymorphism was associated with increased risk of endometrial carcinoma, but no reported study has evaluated the association between the cyclin D1 A870G polymorphism and the risk of EH. We aimed to study the association of cyclin D1 A870G polymorphism with the risk of simple endometrial hyperplasia (SEH) in Egyptian women. Results showed that A allele was associated with a significantly elevated OR of 3.2 (95% CI =2.15 -5.01, P = 0.0001) in SEH cases, and was found to be associated with a significantly elevated OR of 4.03 (95% CI = 2.3 -7.1, P = 0.000) in premenopausal cases, as well as postmenopausal cases (OR of 2.3, 95% CI = 1.18-4.4, P = 0.01). Using the GG genotype as the reference genotype, the AA genotype was associated with a significantly elevated OR of 8.9 (95% CI = 3.7-21.5, P = 0.0001) in SEH cases, and was found to be associated with a significantly elevated OR of 16.4 (95% CI = 4.8-55.5, P = 0.000) in premenopausal cases as well as post-menopausal cases (OR of 4.6 (95% CI = 1.18-18.1, P = 0.02). In conclusion, the common G to A polymorphism in the CCND1 gene is associated with an increased risk of simple endometrial hyperplasia.

Keywords

Recommended Conferences
Share This Page
add_chatinline();
Top