International Journal of Inflammation, Cancer and Integrative Therapy
Open Access

Review Article

Microbiota in Obesity

Faculty of Medicine and Health sciences, University Sultan Zainal Abidin (UniSZA), Terengganu, Malaysia

^*Corresponding Author:

Atif AB
Faculty of Medicine and Health sciences
University Sultan Zainal Abidin (UniSZA), Terengganu, Malaysia
Tel: +6096275587
E-mail: atifamin@unisza.edu.my

Received date: October 30, 2014; Accepted date: November 17, 2014; Published date: November 19, 2014

Citation: Sulaiman I, Farouk RM, Aliya IS, Adzim MKR, Uday YH Abdullah, et al. (2014) Microbiota in Obesity . Interdiscip J Microinflammation 1:118. doi: 10.4172/2381-8727.1000118

Copyright: © 2014, Sulaiman I, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

The obesity epidemic is globally considered as one of the topmost health concern whose multifactorial etiology involves sedentary life style, poor dietary habit, individual’s genetic peculiarity, environmental factors, adipose tissue inflammation and many more. More recently, researchers are intensively focusing on the role of gut microbiome in the manifestation and pathogenesis of obesity and associated complications. Microbiomes modulation of inflammatory responses associated to physiology of obesity implicated the involvement of the Toll-like receptors (TLRs), Short-chain fatty acids (SCFAs) response, gut fermentation mechanisms, as well as passive immune defense exerted by refining of mucous barriers in response to bacterial presence. We reviewhere the role of gut microbiota in the pathogenesis and management of obesity as it relates to metabolic inflammation. Accurate alteration of the gut microbiome appears to be a potential therapeutic intervention that may impede white adipose tissue inflammation and in the long run prevent obesity.