alexa Minocycline Attenuates Severe Hyperglycemia in Patient with Lipodystrophy
ISSN: 2381-8727

International Journal of Inflammation, Cancer and Integrative Therapy
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Case Report

Minocycline Attenuates Severe Hyperglycemia in Patient with Lipodystrophy

Yellowlees Douglas*, Maria B. Grant and Baharak Moshiree

Clinical and Translational Science Institute and Center for Management Communication, PO Box 117150, University of Florida, Gainesville, USA

*Corresponding Author:
Yellowlees Douglas
Clinical and Translational Science Institute and Center for Management Communication
PO Box 117150
University of Florida, Gainesville, USA
Tel: (352) 273-3215
E-mail: [email protected]

Received date: May 21, 2016; Accepted date: June 20, 2016; Published date: June 22, 2016

Citation: Douglas Y, Grant MB, Moshiree B (2016) Minocycline Attenuates Severe Hyperglycemia in Patient with Lipodystrophy. Int J Inflamm Cancer Integr Ther 3:136. doi:10.4172/2381-8727.1000136

Copyright: © 2015 Douglas Y, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Context: Familial partial lipodystrophy (FPL) may appear with metabolic perturbations that include acute insulin resistance and severe hyperglycemia with poor metabolic control despite extremely high doses of insulin.

Objective: We report on a patient with FPL, insulin resistance, and hyperglycemia (fasting glucose >180- 200 mg/dL) on 80 units of U-500 insulin daily. Unexpectedly, the patient responded within two weeks to administration of 100 mg minocycline, a well-tolerated antibiotic with anti-inflammatory properties, achieving good glycemic control with marked reductions in insulin dosage to 15 units daily.

Main outcome measurement: The patient’s blood glucose averaged 130 mg/dL in both fasting and postprandial conditions on 100 units of daily insulin, with no occurrence of hypoglycemia.

Conclusion: Minocycline may improve sensitivity to insulin, even after decades of severe insulin resistance, enabling individuals with FPL to achieve control after the failure of other interventions. This improved glycemic control may help attenuate risk factors for cardiovascular and kidney disease that accompany both diabetes and FPL.


Share This Page

Additional Info

Loading Please wait..
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals


[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version