Myeloid Derived Suppressor Cells: Fuel the Fire | OMICS International | Abstract
ISSN: 2168-9652

Biochemistry & Physiology: Open Access
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Myeloid Derived Suppressor Cells: Fuel the Fire

B. R. Achyut* and Ali S. Arbab
Tumor Angiogenesis Lab, Biochemistry and Molecular Biology Department, Cancer Center, Georgia Regents University, USA
*Corresponding Author : Bhagelu R Achyut, PhD
Tumor Angiogenesis Lab, Cancer Center
Georgia Regents University, 1410 Laney Walker Blvd
CN3144B, Augusta, GA 30912, USA
Tel: 706-721-4375
Fax: 706-434-6406
E-mail: [email protected]
Received July 15, 2014; Accepted July 17, 2014; Published July 24, 2014
Citation: Achyut BR, Arbab AS (2014) Myeloid Derived Suppressor Cells: Fuel the Fire. Biochem Physiol 3:e123. doi:
Copyright: © 2014 Achyut BR, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Low oxygen tension, hypoxia, is a characteristic of many tumors and associated with the poor prognosis. Hypoxia invites bone marrow derived cells (BMDCs) from bone marrow to the site of tumor. These recruited CXCR4+ BMDCs provide favorable environment for the tumor growth by acquiring pro-angiogenic phenotype such as CD45+VEGFR2+ Endothelial Progenitor Cells (EPC), or CD45+Tie2+ myeloid cells. CD11b+ CD13+ myeloid population of the BMDCs modulate tumor progression. These myeloid populations retain immunosuppressive characteristics, for example, myeloid derived suppressor cells (MDSCs), and regulates immune- suppression by inhibiting cytotoxic T cell function. In addition, MDSCs were observed at the premetastatic niche of the distant organs in other tumors. Protumorigenic and prometastatic role of the myeloid cells provides a basis for therapeutic targeting of immunosuppression and thus inhibiting tumor development and metastasis.


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