alexa Neuroleptospirosis: Aseptic Meningoencephalitis or Inva
E-ISSN: 2314-7326
P-ISSN: 2314-7334

Journal of Neuroinfectious Diseases
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Case Report

Neuroleptospirosis: Aseptic Meningoencephalitis or Invasion into the Central Nervous System?

Schiefecker AJ1*, Beer R1, Pfausler B1, Lackner P1, Broessner G1, Kofler M1, Richter S2, Allerberger F2, Muhr T3, Goris M4, Helbok R1 and Schmutzhard E1
1Neurologic Intensive Care Unit, Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria
2AGES (Austrian Agency for Health and Food Safety), Moedling, Austria
3Department of Medicine, Landeskrankenhaus Graz West, Graz, Austria
4Royal Tropical Institute (KIT), KIT Biomedical Research, WHO/FAO/OIE and National Collaborating Centre for Reference and Research on Leptospirosis, Amsterdam, The Netherlands
Corresponding Author : Dr. Alois Josef Schiefecker, M.D.
Neurologic Intensive Care Unit
Department of Neurology
Medical University of Innsbruck
Innsbruck, Austria
Tel: 82-2-958-8295
E-mail: [email protected]
Received: July 18, 2015 Accepted: August 19, 2015 Published: August 22, 2015
Citation: Schiefecker AJ, Beer R, Pfausler B, Lackner P, Broessner G, et al. (2015) Neuroleptospirosis: Aseptic Meningoencephalitis or Invasion into the Central Nervous System?. J Neuroinfect Dis S2:001. doi:10.4172/2314-7326.S2-001
Copyright: © 2015 Schiefecker AJ, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Related article at Pubmed, Scholar Google
 

Abstract

Leptospirosis is a zoonotic disease of global importance with a mortality of up to 50% among patients requiring intensive care medicine. Meningitis or meningoencephalitis due to leptospires are considered to be an immunologically mediated disease and to occur mainly during the second phase of disease. Herein, we report a patient with severe meningo-encephalitis due to leptospirosis with evidence of direct bacterial invasion into the central nervous system (CNS). A 36-year-old otherwise healthy male farmer, without recent travel history, presented with recurrent fever, peaking >39°C, cough and conjunctivitis 10 days after high-pressure cleaning of a piggery without eye protection. Diagnostic work-up revealed meningoencephalitis due to Leptospira species (spp.). Serology (microscopic agglutination test) yielded elevated antibody titers (1:400) for Leptospira interrogans. Polymerase chain reaction (PCR) and electron micrograph of cerebrospinal fluid (CSF) demonstrated direct invasion of Leptospires into the CSF. Magnetic resonance imaging (MRI) of the brain and spine did not reveal any pathologic findings; electroencephalography (EEG) indicated right-hemispheric slowing. Due to severe abdominal pain, gastroscopy was performed. Histology showed signs of vasculitis. Conventional abdominal angiography demonstrated vasculitis resembling panarteriitis nodosa. Combined antibiotic and steroid therapy lead to clinical improvement.

Share This Page

Additional Info

Loading
Loading Please wait..
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords