alexa Novel Insights into the Role of Defensins in Virus-Induced Autoimmunity in the Central Nervous System
E-ISSN: 2314-7326
P-ISSN: 2314-7334

Journal of Neuroinfectious Diseases
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Commentary

Novel Insights into the Role of Defensins in Virus-Induced Autoimmunity in the Central Nervous System

Evangelos I Kazakos1*, Jannis Kountouras1 and Georgia Deretzi2

1Department of Medicine, Second Medical Clinic, Aristotle University of Thessaloniki, Ippokration Hospital, Thessaloniki, Greece

2Department of Neurology, Multiple Sclerosis Unit, Papageorgiou Hospital, Thessaloniki, Greece

*Corresponding Author:
Evangelos I Kazakos
2 El. Venizelou street, 50100, Kozani, Greece
Tel: 00306938114741
E-mail:[email protected]

Received Date: May 06, 2016; Accepted Date: May 31, 2016; Published Date:Jun 03, 2016

Citation: Kazakos EI, Kountouras J, Deretzi G (2016) Novel Insights into the Role of Defensins in Virus-Induced Autoimmunity in the Central Nervous System. J Neuroinfect Dis 7:216. doi:10.4172/2314-7326.1000216

Copyright: © 2016 Kazakos EI, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited

 

Abstract

Virus-induced autoimmunity in the brain, an immune-privileged site, occurs primarily from a breach in thymic selection mechanisms that constitute peripheral tolerance, culminating in a self-directed, Tcell- mediated immune response traditionally thought to occur via molecular or epitope mimicry; immune recognition of novel selfantigens; bystander activation of autoreactive defensin-specific, Tlymphocytes (ATLs); and aberrant expression of cytokines in polyclonically expanded T-cell subsets.

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