alexa Predictors of Drug Induced Hepatotoxicity in Tuberculous Meningitis
E-ISSN: 2314-7326
P-ISSN: 2314-7334

Journal of Neuroinfectious Diseases
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Predictors of Drug Induced Hepatotoxicity in Tuberculous Meningitis

 

Abstract

Background: There is paucity of studies on Drug Induced Hepatitis (DIH) following Anti-Tubercular Therapy (ATT) in the patients with Tuberculosis Meningitis (TBM). In this study, the frequency, spectrum and predictors of DIH in TBM have been reported. Methods: 150 TBM patients without history of prior liver disease were prospectively included. The clinical details, laboratory findings and MRI changes were noted. Presence of seizure, antiepileptic drugs and CSF opening pressure were noted. The diagnosis of DIH was based on 3-5 fold rise in transaminase at least after 3 days of ATT whose baseline liver function was normal without apparent cause of liver dysfunction and >50% improvement in liver function on discontinuation of ATT. The predictors of DIH and its influence on death and outcome at 3, 6 and 9 months were assessed. Results: The median age of the patients was 28.5years. 65 (43.3%) patients developed DIH after a median duration of 22 (3–210) days. After discontinuation of hepatotoxic ATT, the liver function normalized within a median of 13(3-90) days. DIH resulted in repeated interruption of treatment in 18 patients. DIH was related to seizures, raised intracranial pressure, enzyme inducing antiepileptic drugs, and low serum albumin. On multivariate analysis, serum albumin (OR 1.4 95% CI 1.30-13.26, P=0.02) and seizure (OR 1.65 95%CI 1.54-17.53, P=0.01) were independently associated with DIH. Death and functional outcome at 9months were not related to DIH. Conclusion: DIH occurs in 43.3% patients with TBM and is related to hypoalbuminemia and seizure. Attention should be paid to manage under-nutrition and avoid enzyme inducing antiepileptic drugs.

Keywords

Share This Page

Additional Info

Loading
Loading Please wait..
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords