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PTGS2 Effectively Suppress Dendritic Cell Immunity
| M Salahuddin1*, MdSaidur Rahman2, A K Paul3, Md. Selim Ahmed1, and Mohammad Alam Miah4 | |
| 1Department of Biological Sciences, Sungkyunkwan University, Suwon, Gyeonggi-do, South Korea | |
| 2Department of Animal Science and Technology, Chung-Ang University, 4726 Seodong-daero, Anseong, Gyeonggi-Do 456-756, Republic of Korea | |
| 3School of Biotechnology, Suranaree University of Technology, Korat, Thailand | |
| 4Department of Physiology, Faculty of Veterinary Medicine, Bangladesh Agricultural University, Mymensingh, Bangladesh | |
| *Corresponding Author : | M. Salahuddin Department of Biological Sciences, Sungkyunkwan University Suwon, Gyeonggi-do, South Korea Tel: +8210-6492-7621 E-mail: ssdin23@gmail.com |
| Received January 05, 2014; Accepted January 06, 2014; Published January 09, 2014 | |
| Citation: Salahuddin M, Rahman M, Paul AK, Ahmed MS, Miah MA (2014) PTGS2 Effectively Suppress Dendritic Cell Immunity. Biochem Physiol 3:e122. doi:10.4172/2168-9652.1000e122 | |
| Copyright: © 2014 Salahuddin M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | |
Abstract
Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase (COX), is a key enzyme in prostaglandin biosynthesis,regulates dioxygenase and peroxidase activity. The major metabolites of PTGS2 are PGE2, PGF2, PGD2, PGI2, and TXA2. All of these are steroid and act as immunosuppressive agentsbut differ in their regulation of expression and tissue distribution. It is a well-known fact that PTGS2 prompt and aggrandize the cancer condition by proliferation, differentiation, and migration of carcinogenic cells in different organs in animals including human, therefore considered as a novel target for the prevention of cancer. Several researchers have discoverednumerous pharmacological inhibitors of PTGS2 to prevent the cancer,however prevention and treatment of cancer by inhibiting PTGS2 from dendritic cell has not been properly studied. Therefore, indirect/direct molecular silencing of PTGS2 by siRNA/shRNA or PTGS2 knockout from DC to prevent cancer means PTGS2 mediated DC vaccine may be an attractive approach to prevent cancer in near future.
