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Rifampicin-Resistance Tuberculous Meningitis in a Patient with Cerebral Lupus Diagnosed Using Cerebrospinal Xpert Mtb/Rif Test | OMICS International | Abstract
E-ISSN: 2314-7326
P-ISSN: 2314-7334

Journal of Neuroinfectious Diseases
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Case Report

Rifampicin-Resistance Tuberculous Meningitis in a Patient with Cerebral Lupus Diagnosed Using Cerebrospinal Xpert Mtb/Rif Test

Mohamed Faisal Abdul Hamid1*, Soo Chun Ian1, Andrea Ban Yu-Lin1, Mohd Shahrir Mohamed Said1 and Roslina Abdul Manap2
1Respiratory Unit, University Kebangsaan Malaysia Medical Centre, Kuala Lumpur, Malaysia
2Rheumatology Unit, Universiti Kebangsaan Malaysia Medical Centre, Malaysia
Corresponding Author : Mohamed Faisal Abdul Hamid
Respiratory Unit, Universiti Kebangsaan Malaysia Medical Centre
Kuala Lumpur, Malaysia
Tel: +60391455555
Fax: +60391456679
E-mail: [email protected]
Received March 17, 2015; Accepted Novmber 15, 2015; Published Novmber 20, 2015
Citation:Hamid MFA, Ian SC, Yu-Lin AB, Said MSM, Manap RA, (2015)Rifampicin- Resistance Tuberculous Meningitis in a Patient with Cerebral Lupus Diagnosed Using Cerebrospinal Xpert Mtb/Rif Test. J Neuroinfect Dis 6:194. doi:10.4172/2314-7326.1000194
Copyright: © 2015 Hamid MFA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

Tuberculous (TB) meningitis or tubercular meningitis is a Mycobacterium tuberculosis infection of the meninges—the system of membranes which envelop the central nervous system. Molecular tests like the automated rapid molecular assay Xpert® MTB/RIF greatly expedites the detection of M. tuberculosis complex and rifampicin resistance. We report a 22-year old man with cerebral lupus and concurrent rifampicin resistance tuberculous meningitis which was detected by Xpert® MTB/RIF test in the cerebrospinal fluid. The rifampicin resistance in this patient was due to poor compliance. The patient took one tablet of akurit-4 throughout the intensive phase of treatment. This report highlights the usefulness of molecular testing which allowed a faster diagnosis than a bacteriologic confirmation of drug resistant tuberculosis. This is important as early diagnosis and treatment leads to better outcome in TBM.

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