alexa Sandfly Virus Encephalitis in Israel: Two Case Reports
E-ISSN: 2314-7326
P-ISSN: 2314-7334

Journal of Neuroinfectious Diseases
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Case Report

Sandfly Virus Encephalitis in Israel: Two Case Reports and a Review

Regev Cohen1,2*, Babushkin Frida2, Shimoni Zvi1,3, Shapiro Maurice4, Lustig Yaniv5,6 and Brosh-Nissimov Tal7

1The Ruth and Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel

2Infectious Diseases Unit, Sanz Medical Center, Laniado Hospital, Netanya, Israel

3Internal Medicine Department B, Sanz Medical Center, Laniado Hospital, Netanya, Israel

4Intensive Care Unit, Sanz Medical Center, Laniado Hospital, Netanya, Israel

5National Center for Zoonotic Viruses, Central Virology Laboratory, Public Health Services, Israel

6Chaim Sheba Medical Center, Ramat Gan, Israel

7Infectious Diseases Unit, Chaim Sheba Medical Center, Ramat Gan, Israel

*Corresponding Author:
Regev Cohen
Infectious Diseases Unit
Sanz Medical Center, Laniado Hospital
22 Divrei Haim St., 42150, Netanya, Israel
Tel: 972502172175
E-mail: [email protected]

Received date: March 28, 2016; Accepted date: March 22, 2017; Published date: March 24, 2017

Citation: Cohen R, Frida B, Zvi S, Maurice S, Yaniv L, et al. (2017) Sandfly Virus Encephalitis in Israel: Two Case Reports and a Review . J Neuroinfect Dis 8:240. doi:10.4172/2314-7326.1000240

Copyright: © 2017 Cohen R, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Background: Infections due to Sand-fly virus (SFV) are common in the Mediterranean region, but are rarely diagnosed in Israel. Until recently, no cases of severe neuro-invasive SFV infections were reported. In this study, we describe two cases of encephalitis associated with seroconversion to SFV acquired in Israel. We further try to postulate about the infecting strain of the SFV, its local phlebotomine vector, and the reasons for the emergence of this infection in Israel.

Methods: Clinical data were collected from hospital records. Laboratory diagnosis was obtained using mosaic indirect immunofluorescence tests (IFT) against several SFVs.

Results: Two patients with severe encephalitis presented during the same 2014 summer season. Both have acquired their infection in Hasharon district of central coastal Israel. Their encephalitis developed after a prolonged prodrome of 7 and 14 days, and was associated with severe neurological complications. Both patients exhibited a late seroconversion beyond twenty days from symptom onset.

Conclusion: SFVs are possible etiological agents of febrile illnesses and central nervous system infections in Israel. The SFV we report is suspected to be a Toscana virus-like strain, and is probably transmitted by Phlebotomus perfiliewi. A review of the spread of phlebotomine vectors is presented.

Share This Page

Additional Info

Loading Please wait..
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals


[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version