International Journal of Inflammation, Cancer and Integrative Therapy
Open Access

Review Article

The History of Low Dose Medicine Research Review of Preclinical and Clinical Studies with Low Dose SKA Cytokines Since 2009

¹Associate Professor of Physiology, University B.I.S. Group of Institutions, Punjab Technical University, Punjab, India

²Aggregate Professor of Preventive Medicine, Guglielmo Marconi University, Rome, Italy

^*Corresponding Author:

Massimo Fioranelli
Professor, Marconi University
Rome, Italy
Tel: +61 74 9232008
E-mail: massimo.fioranelli@gmail.com

Received date: September 29, 2014; Accepted date: October 20, 2014; Published date: October 22, 2014

Citation: Grazia RM, Fioranelli M (2014) The History of Low Dose Medicine Research Review of Preclinical and Clinical Studies with Low Dose SKA Cytokines Since 2009. Microinflammation 1:115. doi: 10.4172/2381-8727.1000115

Copyright: © 2014, Grazia RM et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Since the second half of the 80s the development of the Psycho-Neuro-Endocrine-Immunology concepts resulted in a change of perspective, from a separatist point of view to an unifying one, relating to the interpretation of the biological functions of the body. A key point was the recognition of the importance of continuous cross-talk between cells, organs and systems in both physiological and pathological conditions based on the fine regulation of the levels of a large number of messenger molecules. Interpreting the pathological phenomenon as an imbalance in intercellular signaling, the administration of low physiological doses of messenger molecules (which act as homeostatic modulating agents) can be considered an intriguing and innovative approach in order to restore the correct intracellular signaling and consequently to restore healthy conditions; these concepts are the milestones of Low Dose Medicine. Five years of scientific research in the field of Low Dose Medicine demonstrated the validity of the conceptual approach and efficacy and safety of the therapeutic intervention based on the oral administration of low doses of activated messenger molecules. This review summarize for the first time the Low Dose Medicine scientific studies published since 2009 and gives a comprehensive overview of the basic and clinical research methodological approaches and results, highlighting the effectiveness of the experimental and clinical use of low dose activated messenger molecules.

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